Comparison of peripapillary choroidal thickness between healthy subjects and patients with Parkinson's disease

PloS One
Elena Garcia-MartinMaria Satue

Abstract

To study peripapillary choroidal thickness (PPCT) in healthy subjects using swept-source optical coherence tomography (SS-OCT), and to evaluate PPCT differences between Parkinson´s disease (PD) patients, and age- and sex-matched healthy controls. Case-control study. 80 healthy subjects and 40 PD patients were consecutively recruited in this single institution study. The healthy subjects were divided into two populations: a teaching population (n = 40, used to establish choroidal zones) and a validating population (n = 40, used to compare measurements with PD patients). An optic disc 6.0×6.0 mm three-dimensional scan was obtained using Deep Range Imaging (DRI) OCT Triton. A 26×26 cube-grid centered on the optic disc was generated to automatically measure choroidal thickness. Five concentric choroidal zones were established and used to compare PPCT between healthy and PD patients. PPCT was significantly thicker in PD patients compared with controls in all four concentric zones evaluated (p≤0.0001). PPCT followed a similar pattern in controls and PD; it was thicker in the temporosuperior region, followed by the superior, temporal, nasal, and inferior regions. PD patients presented with an increased PPCT in all zones surrounding th...Continue Reading

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Oct 23, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I V LitvinenkoD S Maltsev
Mar 10, 2018·Current Medicinal Chemistry·Raffaele MancinoFrancesco Garaci
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Jul 20, 2021·Journal of Parkinson's Disease·Gregory L BrownEsther M Bowie
Aug 28, 2021·Journal of Clinical Medicine·Silvia Mendez-MartinezMaría J Rodrigo

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Software Mentioned

SPSS
DRI
Statistical Package for the Social Sciences ( SPSS
SMARTTrack
OCT
Topcon

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