Comparison of PET/CT and PET/MRI hybrid systems using a 68Ga-labelled PSMA ligand for the diagnosis of recurrent prostate cancer: initial experience.

European Journal of Nuclear Medicine and Molecular Imaging
Ali Afshar-OromiehM C Röthke

Abstract

(68)Ga-labelled HBED-CC-PSMA is a highly promising tracer for imaging recurrent prostate cancer (PCa). The intention of this study was to evaluate the feasibility of PET/MRI with this tracer. Twenty patients underwent PET/CT 1 h after injection of the (68)Ga-PSMA ligand followed by PET/MRI 3 h after injection. Data from the two investigations were first analysed separately and then compared with respect to tumour detection rate and radiotracer uptake in various tissues. To evaluate the quantification accuracy of the PET/MRI system, differences in SUVs between PET/CT and corresponding PET/MRI were compared with differences in SUVs between PET/CT 1 h and 3 h after injection in another patient cohort. This cohort was investigated using the same PET/CT system. With PET/MRI, different diagnostic sequences, higher contrast of lesions and higher resolution of MRI enabled a subjectively easier evaluation of the images. In addition, four unclear findings on PET/CT could be clarified as characteristic of PCa metastases by PET/MRI. However, in PET images of the PET/MRI, a reduced signal was observed at the level of the kidneys (in 11 patients) and around the urinary bladder (in 15 patients). This led to reduced SUVs in six lesions. SUVmea...Continue Reading

References

Nov 30, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Martin HeinischWerner Langsteger
Jul 26, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Marino CimitanMauro G Trovò
Feb 13, 2009·Nuklearmedizin. Nuclear Medicine·Ch SteinerF Buchegger
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
May 17, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Martin LordJean-Paul Vallée
Jun 18, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Shawn M HillierJohn W Babich
Nov 2, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ying ChenMartin G Pomper
Feb 9, 2012·European Journal of Nuclear Medicine and Molecular Imaging·A Afshar-OromiehC M Zechmann
Feb 22, 2012·European Journal of Radiology·Ivan JamborHeikki Minn
Mar 16, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hyunjin ParkMorand Piert
Feb 23, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Patricia Arce-CalisayaMarkus Schwaiger
Mar 7, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Matthias EderUwe Haberkorn
Jul 3, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehMatthias C Roethke
Sep 28, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn

❮ Previous
Next ❯

Citations

May 14, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Raymond Miralbell, Franz Buchegger
Aug 5, 2014·International Journal of Molecular Sciences·Axel Wetter
Feb 20, 2016·Der Urologe. Ausg. A·F NensaA Wetter
Mar 10, 2016·PET Clinics·Lydia Sandiford, Rafael T M de Rosales
Nov 3, 2015·Academic Radiology·Tyler J FraumJonathan McConathy
Nov 20, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Torsten Kuwert, Philipp Ritt
Nov 21, 2014·BJU International·Sebastian MafeldPhilip Haslam
Mar 10, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Laura EvangelistaEmilio Bombardieri
Mar 19, 2016·World Journal of Urology·Francois RozetPeter Hammerer
Mar 24, 2016·Journal of Magnetic Resonance Imaging : JMRI·Houman SotoudehFarrokh Dehdashti
Sep 4, 2015·Biomacromolecules·Adrian V FuchsKristofer J Thurecht
Aug 12, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Thorsten DerlinFrank M Bengel
Aug 20, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·D L BaileyT Beyer
Aug 12, 2015·Nature Reviews. Urology·Paola Mapelli, Maria Picchio
Nov 22, 2014·Abdominal Imaging·Matthias EiberMarkus Schwaiger
Apr 3, 2015·Annals of Nuclear Medicine·Enza CapassoSiroos Mirzaei
May 28, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Markus DietleinBernd Neumaier
Feb 13, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·D L BaileyT Beyer
Jan 18, 2015·European Journal of Nuclear Medicine and Molecular Imaging·M PicchioS Fanti
Feb 13, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Monique R BernsenMarion de Jong
Nov 21, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Sep 25, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Thomas KrohnFlorian F Behrendt
Apr 28, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Felix M MottaghyFrederik A Verburg
Apr 26, 2016·Clinical Radiology·F de Galiza BarbosaP Veit-Haibach
May 22, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Christian H PfobMatthias Eiber
Oct 16, 2016·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·M R GrootendorstA Purushotham
Jun 10, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Isabel RauscherMatthias Eiber
Jun 17, 2016·Future Oncology·Kevin C McCammackDaniel Ja Margolis
Sep 7, 2016·PET Clinics·Andreas Kjær, Drew A Torigian
Jul 18, 2016·Revista española de medicina nuclear e imagen molecular·C Riola-ParadaJ L Carreras-Delgado
Aug 17, 2016·Future Oncology·Francesca V MertanBaris Turkbey
Nov 9, 2016·Seminars in Nuclear Medicine·Liza LindenbergPeter Choyke
Oct 25, 2016·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·L Michaud, K A Touijer
Oct 30, 2016·Expert Review of Molecular Diagnostics·Martin BarrioKen Herrmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.