Abstract
We sought to examine the influence on the brain, with or without old infarction, of pH management during antegrade selective cerebral perfusion in a canine model. A cerebral infarct canine model was created by injecting a cylindrical silicone embolus. Dogs that had obvious neurologic deficits and had survived for 4 weeks or more were included in the model. Deep hypothermia with antegrade selective cerebral perfusion was performed in intact mongrel dogs (alpha-stat: group A, n = 6; pH-stat: group B, n = 6) and mongrel dogs with infarctions (alpha-stat: group C, n = 6; pH-stat: group D, n = 6). Maxillary vein saturation of oxygen, venous-arterial lactate difference, and serum concentrations of malondialdehyde and glutamate were measured and central conduction times and amplitude in somatosensory evoked potentials were assessed during the operation. During the experimental procedure, the maxillary vein saturation of oxygen was significantly less (P <.05), whereas the venous-arterial lactate difference was significantly greater (P <.05) in the cooling phase to 28 degrees C in group C than in the other groups. The pH-stat group showed significantly greater arterial Paco(2) and lower pH than the alpha-stat group during the period bet...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jul 19, 1991·Brain Research·A SakamotoR Ogawa
Apr 1, 1989·Journal of Neuroscience Methods·C W VanderzantL G D'Alecy
Feb 1, 1985·Journal of Neurosurgery·K L MeyerD L Donaldson
Jan 1, 1974·Stroke; a Journal of Cerebral Circulation·A L SmithC P Larson
Aug 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·J M MurkinC J Wong
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K TakagiR Busto
May 1, 1996·The Annals of Thoracic Surgery·T SakuradaS Komatsu
Jun 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·R L PatelG E Venn
Dec 19, 1996·The New England Journal of Medicine·G W RoachC Ley
Jan 22, 1998·The Journal of Thoracic and Cardiovascular Surgery·A J du PlessisJ W Newburger
Jul 3, 1999·The Annals of Thoracic Surgery·K M DosscheF E Vermeulen
Oct 3, 1999·Journal of Neurosurgery·J W SleighD Ulyatt
Aug 2, 2000·The Annals of Thoracic Surgery·T KazuiY Tamiya
Feb 15, 2001·The Journal of Thoracic and Cardiovascular Surgery·M A PriestleyC D Kurth
Mar 10, 2001·The Journal of Thoracic and Cardiovascular Surgery·T KazuiM Takinami
Jun 1, 2001·The Journal of Thoracic and Cardiovascular Surgery·C HaglR B Griepp
Oct 3, 2001·The Journal of Thoracic and Cardiovascular Surgery·N WashiyamaS Yamamoto
Sep 10, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kuniaki OgasawaraTakashi Yoshimoto
Nov 26, 2002·The Journal of Thoracic and Cardiovascular Surgery·Marco Di EusanioKarl M Dossche
Nov 26, 2002·The Journal of Thoracic and Cardiovascular Surgery·Tadaomi-Alfonso Miyamoto, Koho-Julio Miyamoto
Citations
Oct 23, 2012·General Thoracic and Cardiovascular Surgery·Norihiko Shiiya
May 1, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Maximilian LuehrChristian D Etz
Dec 26, 2012·The Journal of Thoracic and Cardiovascular Surgery·David SpielvogelSteven L Lansman
Apr 1, 2008·The Journal of Thoracic and Cardiovascular Surgery·James C HalsteadRandall B Griepp
Aug 28, 2007·The Annals of Thoracic Surgery·Sebastian DahlbackaTatu Juvonen
Feb 27, 2007·The Journal of Thoracic and Cardiovascular Surgery·Takayasu SuzukiMichio Fujie
Jun 25, 2005·The Annals of Thoracic Surgery·David SpielvogelRandall B Griepp
Jan 30, 2007·The Annals of Thoracic Surgery·David SpielvogelRandall B Griepp
Oct 21, 2016·General Thoracic and Cardiovascular Surgery·Michael O Kayatta, Edward P Chen