Comparison of pH management during antegrade selective cerebral perfusion in canine models with old cerebral infarction

The Journal of Thoracic and Cardiovascular Surgery
Kazuhiro OhkuraKentaro Ohishi

Abstract

We sought to examine the influence on the brain, with or without old infarction, of pH management during antegrade selective cerebral perfusion in a canine model. A cerebral infarct canine model was created by injecting a cylindrical silicone embolus. Dogs that had obvious neurologic deficits and had survived for 4 weeks or more were included in the model. Deep hypothermia with antegrade selective cerebral perfusion was performed in intact mongrel dogs (alpha-stat: group A, n = 6; pH-stat: group B, n = 6) and mongrel dogs with infarctions (alpha-stat: group C, n = 6; pH-stat: group D, n = 6). Maxillary vein saturation of oxygen, venous-arterial lactate difference, and serum concentrations of malondialdehyde and glutamate were measured and central conduction times and amplitude in somatosensory evoked potentials were assessed during the operation. During the experimental procedure, the maxillary vein saturation of oxygen was significantly less (P <.05), whereas the venous-arterial lactate difference was significantly greater (P <.05) in the cooling phase to 28 degrees C in group C than in the other groups. The pH-stat group showed significantly greater arterial Paco(2) and lower pH than the alpha-stat group during the period bet...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Apr 1, 1989·Journal of Neuroscience Methods·C W VanderzantL G D'Alecy
Feb 1, 1985·Journal of Neurosurgery·K L MeyerD L Donaldson
Jan 1, 1974·Stroke; a Journal of Cerebral Circulation·A L SmithC P Larson
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K TakagiR Busto
May 1, 1996·The Annals of Thoracic Surgery·T SakuradaS Komatsu
Jan 22, 1998·The Journal of Thoracic and Cardiovascular Surgery·A J du PlessisJ W Newburger
Jul 3, 1999·The Annals of Thoracic Surgery·K M DosscheF E Vermeulen
Oct 3, 1999·Journal of Neurosurgery·J W SleighD Ulyatt
Mar 10, 2001·The Journal of Thoracic and Cardiovascular Surgery·T KazuiM Takinami
Oct 3, 2001·The Journal of Thoracic and Cardiovascular Surgery·N WashiyamaS Yamamoto
Sep 10, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kuniaki OgasawaraTakashi Yoshimoto
Nov 26, 2002·The Journal of Thoracic and Cardiovascular Surgery·Tadaomi-Alfonso Miyamoto, Koho-Julio Miyamoto

❮ Previous
Next ❯

Citations

Oct 23, 2012·General Thoracic and Cardiovascular Surgery·Norihiko Shiiya
May 1, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Maximilian LuehrChristian D Etz
Dec 26, 2012·The Journal of Thoracic and Cardiovascular Surgery·David SpielvogelSteven L Lansman
Apr 1, 2008·The Journal of Thoracic and Cardiovascular Surgery·James C HalsteadRandall B Griepp
Feb 27, 2007·The Journal of Thoracic and Cardiovascular Surgery·Takayasu SuzukiMichio Fujie
Jun 25, 2005·The Annals of Thoracic Surgery·David SpielvogelRandall B Griepp
Jan 30, 2007·The Annals of Thoracic Surgery·David SpielvogelRandall B Griepp
Oct 21, 2016·General Thoracic and Cardiovascular Surgery·Michael O Kayatta, Edward P Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
James C HalsteadRandall B Griepp
© 2021 Meta ULC. All rights reserved