Comparison of pharmacological and binding assays for ten beta-adrenoceptor blocking agents and two beta-adrenoceptor agonists

British Journal of Pharmacology
N BiethJ Velly


1 The inhibition constants evaluated by binding assays for ten beta-adrenoceptor blocking agents and two beta-adrenoceptor agonists, were compared with the pA2 and pD2 values determined in vitro and in vivo. 2 There was only a limited correlation between beta 1 or beta 2 selectivities observed with the different methods. 3 Selectivity is generally less pronounced in binding assays than for in vivo and in vitro experiments.


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Related Concepts

Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Norepinephrine Receptors
Beta-adrenergic receptor
Rats, Laboratory
In Vitro [Publication Type]

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