Comparison of pharmacological and binding assays for ten beta-adrenoceptor blocking agents and two beta-adrenoceptor agonists

British Journal of Pharmacology
N BiethJ Velly

Abstract

1 The inhibition constants evaluated by binding assays for ten beta-adrenoceptor blocking agents and two beta-adrenoceptor agonists, were compared with the pA2 and pD2 values determined in vitro and in vivo. 2 There was only a limited correlation between beta 1 or beta 2 selectivities observed with the different methods. 3 Selectivity is generally less pronounced in binding assays than for in vivo and in vitro experiments.

References

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Citations

Oct 1, 1987·Pharmacology, Biochemistry, and Behavior·E B EvansW Slikker
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·M L Cohen, L M Hynes
Dec 15, 1985·Thrombosis Research·K WintherP H Andersen
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Related Concepts

Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Metazoa
Lung
Myocardium
Norepinephrine Receptors
Beta-adrenergic receptor
Rats, Laboratory
In Vitro [Publication Type]

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