Comparison of phase-contrast MR and flow simulations for the study of CSF dynamics in the cervical spine

The Neuroradiology Journal
Erika Kristina LindstrømKent-Andre Mardal

Abstract

Background Investigators use phase-contrast magnetic resonance (PC-MR) and computational fluid dynamics (CFD) to assess cerebrospinal fluid dynamics. We compared qualitative and quantitative results from the two methods. Methods Four volunteers were imaged with a heavily T2-weighted volume gradient echo scan of the brain and cervical spine at 3T and with PC-MR. Velocities were calculated from PC-MR for each phase in the cardiac cycle. Mean pressure gradients in the PC-MR acquisition through the cardiac cycle were calculated with the Navier-Stokes equations. Volumetric MR images of the brain and upper spine were segmented and converted to meshes. Models of the subarachnoid space were created from volume images with the Vascular Modeling Toolkit. CFD simulations were performed with a previously verified flow solver. The flow patterns, velocities and pressures were compared in PC-MR and CFD flow images. Results PC-MR images consistently revealed more inhomogeneous flow patterns than CFD, especially in the anterolateral subarachnoid space where spinal nerve roots are located. On average, peak systolic and diastolic velocities in PC-MR exceeded those in CFD by 31% and 41%, respectively. On average, systolic and diastolic pressure gr...Continue Reading

References

Mar 6, 2010·AJNR. American Journal of Neuroradiology·Andrew L WentlandV M Haughton
Apr 21, 2012·AJNR. American Journal of Neuroradiology·G RutkowskaK-A Mardal
Jul 19, 2013·The Neuroradiology Journal·K-A MardalV Haughton

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Citations

Oct 26, 2018·International Journal for Numerical Methods in Biomedical Engineering·Luca PossentiPaolo Zunino
Jul 14, 2020·International Journal for Numerical Methods in Biomedical Engineering·Tobias KöpplBarbara Wohlmuth
Jul 18, 2020·Fluids and Barriers of the CNS·Elena JaegerAlexander C Bunck

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Software Mentioned

Paraview
Vascular Modelling Tool Kit
MatLab
MR
PC

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