Comparison of planned versus actual dose delivered for external beam accelerated partial breast irradiation using cone-beam CT and deformable registration

International Journal of Radiation Oncology, Biology, Physics
Yasmin HasanFrank A Vicini

Abstract

To assess the adequacy of dose delivery to the clinical target volume (CTV) using external beam (EB) accelerated partial breast irradiation (APBI). Sixteen patients treated with EB APBI underwent cone beam CT (CBCT) before each fraction and daily helical CT (HCT) scans to determine setup errors and calculate the dose per fraction. For 12 patients, an in-house image-intensity-based deformable registration program was used to register the HCTs to the planning CT and generate the cumulative dose. Treatment was 38.5 Gy in 10 fractions. EB APBI constraints from the National Surgical Adjuvant Breast and Bowel Project B39/Radiation Therapy Oncology Group 0413 Phase III protocol were used. The mean setup error per CBCT registration was 9 ± 5 mm. Dose-volume histogram analysis showed only one patient (8%) with a decrease in the CTV V90 (8% underdosage). All other patients demonstrated adequate target coverage. PTV_EVAL V90 was on average 3% (range, 0%-16%) less than planned. For the ipsilateral breast, four patients had an increase in V50 (≤ 1% increase) and three patients had an increase in V100 (≤ 9% increase). Only one patient showed an increase >5%. Four patients had an increase in ipsilateral lung V30 (maximum 3%), and one had an i...Continue Reading

References

Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Daniel W WeedJohn Wong
Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Silvia C FormentiJ Keith Dewyngaert
Feb 22, 2005·Medical Physics·David Djajaputra, Shidong Li
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Apr 1, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maria Francesca SpadeaAntonio Pedotti
Apr 10, 2007·International Journal of Radiation Oncology, Biology, Physics·Elizabeth A WhiteDavid A Jaffray
Oct 31, 2007·International Journal of Radiation Oncology, Biology, Physics·Leonard H KimDi Yan
Jan 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Yasmin HasanDi Yan

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Citations

Oct 23, 2014·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Marko LaaksomaaPirkko-Liisa Kellokumpu-Lehtinen
Feb 13, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Thomas MulliezLiv Veldeman
Jul 25, 2015·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Taylor HarryLaura Cerviño
Dec 3, 2014·International Journal of Radiation Oncology, Biology, Physics·Christine H FengHania A Al-Hallaq
Aug 25, 2016·Practical Radiation Oncology·Vikneswary BatumalaiGeoff P Delaney
Sep 8, 2012·Journal of Applied Clinical Medical Physics·Eduard SchreibmannTim Fox
Aug 22, 2018·Journal of the Belgian Society of Radiology·Paolo Simoni

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