PMID: 11317518Apr 25, 2001Paper

Comparison of plasma component levels in four strains of female mice with different mammary tumour potentials

In Vivo
H Nagasawa, S Kusakawa

Abstract

Based on the importance of general metabolic activity to mammary tumourigenesis, plasma component levels were examined at 6 and 10 months of age in female virgin mice of four strains, which in mammary tumour potential, rank in the descending order of SHN, GR/A, SLN and C3H/He. The plasma aspartate aminotransferase level elevated from 6 to 10 months of age in the SHN and GR/A, but not in the SLN and C3H/He strains. The total bilirubin level was higher in the former two strains than the latter two at both 6 and 10 months. The blood urea nitrogen level was highest in SHN. C3H/He had the lowest plasma levels of these components as well as amylase at both ages. The results indicate the signifcance to the mammary tumourigenic potential of plasma levels of certain components related to general metabolic activity.

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