PMID: 9525032Apr 3, 1998Paper

Comparison of plasma fentanyl concentrations by using three transdermal fentanyl patch sizes in dogs

Veterinary Surgery : VS
C M EggerP H Cribb

Abstract

To compare plasma fentanyl concentrations attained after the application of three transdermal fentanyl patch sizes (50, 75, and 100 micrograms/hour) in dogs. Repeated Latin square controlled study. Six intact, mixed-breed adult dogs (2 males, 4 females) weighing 19.9 +/- 3.4 kg. Each dog was randomly assigned to receive each of three treatments: 50 (P50), 75 (P75), or 100 (P100) micrograms/hour transdermal patches. Patches were left in place for 72 hours. Jugular venous blood was collected at 1, 2, 4, 8, 12, 24, 36, 48, 60, and 72 hours after patch application and for 1, 2, 4, 8, and 12 hours after patch removal. Plasma fentanyl concentrations were measured using a radioimmunoassay technique. After a 96-hour washout period, each dog was moved to another treatment group and received a different patch size. The following results were obtained (mean +/- SD): average plasma fentanyl concentration from 24 to 72 hours, 0.7 +/- 0.2 ng/mL (P50), 1.4 +/- 0.5 ng/mL (P75), 1.2 +/- 0.5 ng/mL (P100); the total area under the concentration versus time curve (0 hours to infinity), 46 +/- 12.2 ng/h/mL (P50), 101.2 +/- 41.4 ng/h/mL (P75), 80.4 +/- 38.3 ng/h/mL (P100); and the apparent elimination half-life, 3.6 +/- 1.2 hours (P50), 3.4 +/- 2.7 ...Continue Reading

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Citations

Jan 29, 2003·Journal of the American Animal Hospital Association·Steven L Marks, Joseph Taboada
Aug 10, 2000·The Veterinary Clinics of North America. Small Animal Practice·K A Mathews
Oct 29, 2008·The Veterinary Clinics of North America. Small Animal Practice·James S Gaynor
Aug 14, 2012·Veterinary Anaesthesia and Analgesia·Sonja A AghighiSabine B R Kästner
Feb 18, 2011·Journal of Veterinary Pharmacology and Therapeutics·E BelleiA Zaghini
Jul 14, 2012·Veterinary Anaesthesia and Analgesia·Jack-Yves DeschampsFrançoise A Roux
Oct 3, 2006·Research in Veterinary Science·P C Mills, S E Cross
Dec 6, 2005·The Veterinary Journal·P C Mills, S E Cross
Apr 8, 1999·Clinical Techniques in Small Animal Practice·J E Ilkiw
Feb 9, 2005·The Veterinary Clinics of North America. Small Animal Practice·Vicki L Campbell
Jan 28, 2015·Basic & Clinical Pharmacology & Toxicology·Emma M HeikkinenAki T Heikkinen
Jun 15, 2000·The Veterinary Clinics of North America. Small Animal Practice·C A Brady, L G King
May 20, 1999·The Veterinary Clinics of North America. Small Animal Practice·G L Carroll
Jul 23, 2004·Veterinary Anaesthesia and Analgesia·Michael YackeyLinda D Tripp
Jan 24, 2007·Veterinary Anaesthesia and Analgesia·Chad W Schmiedt, Dale E Bjorling
Nov 25, 2003·Pharmacology & Toxicology·Rikke H LarsenJesper B Nielsen
Nov 3, 2010·Physiologia Plantarum·Wei ChangHong Hu
Jan 18, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·L WeilandF Gasthuys
Oct 6, 2000·Journal of the American Veterinary Medical Association·J N FranksD M Boothe
Apr 4, 2006·Journal of the American Veterinary Medical Association·Diane WilsonGiselle Hosgood
Mar 9, 2004·Journal of the American Veterinary Medical Association·Charisse D DavidsonJack D Henry
Nov 10, 2004·Journal of the American Animal Hospital Association·Erik H Hofmeister, Christine M Egger
Aug 10, 2000·The Veterinary Clinics of North America. Small Animal Practice·P J Pascoe
Dec 26, 2021·Veterinary Medicine and Science·Vincenzo CicirelliGiovanni M Lacalandra

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