Comparison of plasma lipid and lipoprotein profiles in hypertensive black versus white men. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents

The American Journal of Cardiology
M R LakshmanE D Freis

Abstract

An abnormal plasma lipid and lipoprotein profile is an independent and strong predictor of mortality and morbidity from coronary artery disease (CAD). We report on plasma lipid and lipoprotein profiles with respect to race, age, obesity, blood pressure (BP), smoking, and drinking history in 1,292 male veterans with a diastolic BP of 95 to 109 mm Hg while off antihypertensive medications. Blacks had 24% (p <0.001) lower triglycerides than whites. In contrast, the following parameters were higher in blacks than in whites by the indicated percentages: high-density lipoprotein (HDL) cholesterol, 16% (p <0.001); HDL2 cholesterol, 36% (p <0.001); apolipoprotein (Apo) A1, 8% (p <0.001); HDL/low-density lipoprotein (LDL), 18% (p = 0.018); HDL2/LDL, 36% (p = 0.031); HDL2/HDL3, 21% (p <0.001); and Apo A1/Apo B, 15% (p <0.001). Triglycerides were unchanged up to age 60, but were lower by 24% (p <0.001) in those aged > or = 70. Apo A1 levels were higher (p <0.001), whereas LDL cholesterol was lower (p <0.008) in moderate alcohol consumers versus abstainers. Triglycerides were higher (p <0.001), whereas HDL, HDL2 cholesterol, and Apo A1 were lower (p <0.001) with increasing obesity. Moderate alcohol consumption had a strong favorable effect...Continue Reading

References

Jun 1, 1991·Diabetes Care·A M Fontbonne, E M Eschwège
Jun 1, 1990·Diabetes Care·R W Stout
Aug 1, 1985·Journal of Hypertension·P WeidmannA Gerber
Feb 20, 1986·The New England Journal of Medicine·R Ross
Mar 1, 1986·Alcoholism, Clinical and Experimental Research·P CushmanJ Kalbfleisch
Aug 1, 1986·American Heart Journal·W P Castelli
Nov 28, 1986·JAMA : the Journal of the American Medical Association·W P CastelliW B Kannel
Jan 24, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·J P BaarkL Hemmingsen
Aug 18, 1983·The New England Journal of Medicine·J J MaciejkoS J Mao
Feb 11, 1983·JAMA : the Journal of the American Medical Association·G H HartungA M Gotto

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Citations

Dec 17, 2009·Genes & Nutrition·Raj LakshmanSamir Zakhari
Oct 18, 2003·Metabolism: Clinical and Experimental·Manjunath N RaoM Raj Lakshman
Aug 10, 2005·The Journal of Clinical Hypertension·Jayabal PanneerselvamNamasivayam Nalini
Aug 5, 2000·The Journal of the Royal Society for the Promotion of Health·J A PapadakisD P Mikhailidis
May 21, 2003·Journal of Human Hypertension·A E SchutteJ H de Ridder

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