Comparison of Positron Emission Tomography Quantification Using Magnetic Resonance- and Computed Tomography-Based Attenuation Correction in Physiological Tissues and Lesions: A Whole-Body Positron Emission Tomography/Magnetic Resonance Study in 66 Patients

Investigative Radiology
Ferdinand SeithNina Schwenzer

Abstract

Attenuation correction (AC) in fully integrated positron emission tomography (PET)/magnetic resonance (MR) systems plays a key role for the quantification of tracer uptake. The aim of this prospective study was to assess the accuracy of standardized uptake value (SUV) quantification using MR-based AC in direct comparison with computed tomography (CT)-based AC of the same PET data set on a large patient population. Sixty-six patients (22 female; mean [SD], 61 [11] years) were examined by means of combined PET/CT and PET/MR (11C-choline, 18F-FDG, or 68Ga-DOTATATE) subsequently. Positron emission tomography images from PET/MR examinations were corrected with MR-derived AC based on tissue segmentation (PET(MR)). The same PET data were corrected using CT-based attenuation maps (μ-maps) derived from PET/CT after nonrigid registration of the CT to the MR-based μ-map (PET(MRCT)). Positron emission tomography SUVs were quantified placing regions of interest or volumes of interest in 6 different body regions as well as PET-avid lesions, respectively. The relative differences of quantitative PET values when using MR-based AC versus CT-based AC were varying depending on the organs and body regions assessed. In detail, the mean (SD) relativ...Continue Reading

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Citations

Dec 15, 2015·Magnetic Resonance Imaging·Koji SagiyamaHiroshi Honda
Apr 10, 2017·Magnetic Resonance Imaging Clinics of North America·Jorge D OldanTracy Lynn Rose
Nov 1, 2017·Journal of Magnetic Resonance Imaging : JMRI·Chiara GiraudoMarius E Mayerhoefer
Apr 12, 2018·Investigative Radiology·Marius E MayerhoeferAlexander Haug
Dec 31, 2019·BioMed Research International·Guobing LiuHongcheng Shi
Nov 13, 2020·BJR Open·Georg Schramm, Claes Nøhr Ladefoged
Aug 17, 2021·Radiologic Clinics of North America·Farshad MoradiJonathan McConathy

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