PMID: 9416737Jan 7, 1998Paper

Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain

Anesthesiology
Timothy J BrennanPeter K Zahn

Abstract

Preclinical studies in experimental animals suggest that preemptive analgesia may improve postoperative pain management. The beneficial effects of preemptive analgesia appear less remarkable clinically. The purpose of this study is to examine the effect of pre- and post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model for postoperative pain. Rats with intrathecal catheters were anesthetized with halothane, and the surgical field was prepared. A saline vehicle or the test drug was administered 15 min before an incision was made in the plantar aspect of the hindpaw or after the incision was completed. After recovery, mechanical hyperalgesia to punctate and nonpunctate stimuli was measured. Rats were tested on the day of surgery for the first 5 h and each day for 6 days. In saline vehicle-treated rats, the median withdrawal threshold decreased from 522 mN to 54 mN or less, and the response frequency to pressure from application of the plastic disc increased from 0 +/- 0% to 96 +/- 12% or greater after incision. Hyperalgesia was persistent through 2 days after surgery and then gradually returned toward preincision values over the next 4 days. Pre- or postincision administration of either in...Continue Reading

References

Feb 1, 1990·Anaesthesia·H J McQuay, A H Dickenson
Jan 1, 1990·Anesthesia and Analgesia·M TverskoyI Kissin
Feb 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A FassoulakiD Papoulia
Jul 10, 1993·Lancet·C E RichmondC J Woolf
Apr 1, 1994·British Journal of Anaesthesia·H Kehlet
Apr 1, 1993·British Journal of Anaesthesia·J B Dahl, H Kehlet
Mar 1, 1996·Pain·T J BrennanG F Gebhart
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy

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Citations

May 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Shiro KoizukaFumio Goto
Aug 25, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M NaguibA H Samarkandi
Jun 15, 2001·ILAR Journal·Timothy J. Brennan
Oct 10, 2002·Regional Anesthesia and Pain Medicine·Peter K ZahnTimothy J Brennan
Jun 6, 2003·Journal of the American Veterinary Medical Association·David R GrossKurt A Grimm
Oct 5, 2006·Current Opinion in Anaesthesiology·J Ballantyne
Sep 9, 2006·Current Opinion in Anaesthesiology·Esther M Pogatzki-Zahn, Peter K Zahn
Oct 6, 2000·Anesthesiology·I Kissin
Oct 25, 2000·Anesthesiology·E P Vandermeulen, T J Brennan
Mar 2, 2002·Anesthesiology·Quinn H Hogan
Nov 12, 2015·Pharmaceutical Research·Haibo QuPaul Ducheyne
Mar 1, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yeong-Ray WenChia-Chuan Wang
Mar 21, 2012·Revista española de anestesiología y reanimación·V Pedroviejo Sáez
Aug 19, 2009·European Journal of Pharmacology·Mónica Ambriz-TututiVinicio Granados-Soto
Nov 28, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Theodoros PapathanasiouTrine Meldgaard Lund
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Esther M Pogatzki-ZahnTimothy J Brennan
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Sina Grape, Martin R Tramèr
Mar 2, 2005·European Journal of Pain : EJP·Jürgen Sandkühler, Ruth Ruscheweyh
Nov 5, 2003·British Journal of Pharmacology·Garth T WhitesideKatharine Walker
Mar 15, 2005·Anesthesiology Clinics of North America·Timothy J BrennanEsther M Pogatzki-Zahn
Nov 20, 2002·Expert Opinion on Pharmacotherapy·Allan GottschalkE Andrew Ochroch
Aug 3, 2013·Journal of Ethnopharmacology·Cristiani I B WalkerJuliano Ferreira
Oct 27, 2016·PloS One·Aurelie ThomasMatthew Leach
Dec 18, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A Prado, R M C Pontes
Mar 12, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A Prado, E B Machado Filho
Dec 22, 1999·Anesthesiology·P M Dougherty, P S Staats
May 6, 2008·Australian Veterinary Journal·S LomaxP A Windsor

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