Abstract
This was designed to compare vincristine-prednisone (VP) vs. prednisolone, vincristine, methotrexate, and 6-mercaptopurine (POMP) with respect to response rates and toxicity for induction therapy in acute leukemia. Children with acute lymphoblastic, acute undifferentiated, or acute stem cell leukemia were stratified on the basis of initial leukocyte count and age, then randomly assigned to POMP or VP induction therapy. On the POMP regime, 19/34 (56%) achieved complete remission (CR), 7 achieved partial remission (PR), and 5 did not respond (NR). Three died prior to day 25 of the study. On the VP regime, 37/39 (95%) had CR, and 2 NR. On the VP regime neither sepsis nor toxicity were significant problems. The POMP regime had a higher incidence of sepsis and other toxicities frequently causing therapy interruption, but not enequivocally causing the poor response rate. Several other factors were evaluated as possible causes for the lack of response to POMP therapy.
Citations
Sep 1, 1988·Indian Journal of Pediatrics·V P Choudhry, L S Arya
Nov 1, 1983·Indian Journal of Pediatrics·V P ChoudhryA K Sarya
Mar 1, 1983·The Journal of Pediatrics·D M KompS McIntosh
Jan 1, 1977·Medical and Pediatric Oncology·S E SallanN Jaffe
Jan 1, 1980·Medical and Pediatric Oncology·B M CamittaS Lauer
Jan 1, 1983·Critical Reviews in Oncology/hematology·L P Miller, D R Miller
Apr 15, 1991·Cancer·K FoucarC R Key
Oct 1, 1978·Cancer·F Sackmann-MurielJ Saslavsky
Jun 1, 1997·Journal of Pediatric Surgery·J SadoffN Spigland
Sep 1, 1980·Cancer·D H BerryT J Vietti
Sep 15, 1982·Cancer·D M KompJ Shuster
Jun 15, 1980·Cancer·G H ReamanD G Poplack
Jan 1, 1979·Cancer·S D SmithJ T Lowman
Dec 15, 1982·Cancer·S J BertoloneC C Patel