Comparison of preemptive ibuprofen, acetaminophen, and placebo administration in reducing peri- and postoperative pain in primary tooth extraction: A randomized clinical trial.

Clinical and Experimental Dental Research
Nabih Raslan, Toufic Zouzou

Abstract

The management of pain resulting from anesthesia injection, tooth extraction and in the period after extraction is of great importance in pediatric dentistry. The aim of this study was to compare the efficacy of the preemptive administration of ibuprofen or acetaminophen with placebo in reducing the pain during injection, extraction and postoperatively in children undergoing primary tooth extraction. A randomized, placebo-controlled, triple-blinded clinical trial of cooperative children who needed primary molar extraction by local anesthesia. Sixty-six children aged between 6 and 8 years were randomly assigned to one of three groups: (a) Acetaminophen syrup (320 mg/10 ml); (b) placebo solution; and (c) ibuprofen syrup (200 mg/10 ml). Each of the three solutions was given 30 min before administration of the local anesthetic agent. The Pain level was assessed using the Wong-Baker faces® pain rating scale after injection, extraction, and postoperatively. The Kruskal-Wallis and Mann-Whitney U test were used to evaluate the pain scores between groups at confidence level of 95%. The use of preemptive analgesics showed lower pain scores compared to placebo. Additionally, only ibuprofen significantly reduced pain scores compared to pla...Continue Reading

References

May 1, 1993·Clinical Pharmacology and Therapeutics·B P Schachtel, W R Thoden
Jan 6, 2001·The Journal of the American Dental Association·Y NakaiD S Ramsay
Oct 30, 2001·The Journal of the American Dental Association·M J WahlM Muldoon
Feb 28, 2003·International Journal of Paediatric Dentistry·S JürgensD S Gooneratne
Feb 28, 2004·European Journal of Pain : EJP·David A PerrottG David Champion
Feb 8, 2006·Archives of Pediatrics & Adolescent Medicine·E Michael SarrellHerman Avner Cohen
Jun 20, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Amaury Pozos-GuillenJose Perez-Urizar
Dec 2, 2009·Inflammopharmacology·K D Rainsford
Jun 18, 2010·Anesthesia Progress·Daniel E Becker
Jan 10, 2012·The British Journal of Oral & Maxillofacial Surgery·Mario Alberto Isiordia-EspinozaVinicio Granados-Soto
Nov 28, 2012·International Journal of Clinical Practice. Supplement·D R Mehlisch, J Sykes
Dec 19, 2012·International Journal of Environmental Research and Public Health·Maurício A OliveiraJúnia M Serra-Negra
Sep 9, 2018·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·M GhaneiA Robertson
Oct 6, 2018·The Journal of Clinical Pediatric Dentistry·Johnny KharoubaSigalit Blumer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.