Comparison of Prevention of NSAID-Induced Gastrointestinal Complications by Rebamipide and Misoprostol: A Randomized, Multicenter, Controlled Trial-STORM STUDY

Journal of Clinical Biochemistry and Nutrition
Soo-Heon ParkComson Lertkupinit

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects such as dyspepsia, peptic ulcer, hemorrhage, and perforation. Misoprostol and PPIs have been used to prevent NSAID-induced gastroduodenal injury. Rebamipide increases gastric mucus and stimulates the production of endogenous prostaglandins. The prophylactic effect of rebamipide on NSAID-induced gastrointestinal complications is unknown. The aim of this study was to compare NSAID-induced gastrointestinal complications in rebamipide- and misoprostol-treated groups. Patients were randomized to two groups and took a conventional NSAID plus rebamipide or misoprostol for 12 weeks. Gastric mucosal damage was evaluated by endoscopy at screening and the end of the study. The prevalences of active gastric ulcer were 7/176 (3.9%) in the rebamipide group and 3/156 (1.9%) in the misoprostol group. The prevalences of peptic ulcer were 8/176 (4.5%) in the rebamipide group and 7/156 (4.4%) in the misoprostol group. The cumulative incidences of peptic ulcer in the high-risk subgroup were 6/151 (4.0%) for rebamipide and 6/154 (3.9%) for misoprostol. In conclusion, rebamipide prevented NSAID-induced peptic ulcer as effectively as misoprostol in patients on long-term ...Continue Reading

References

Nov 1, 1995·The American Journal of Physiology·J E Grønbech, E R Lacy
Mar 21, 1998·Digestive Diseases and Sciences·T OkumuraY Kohgo
Oct 24, 2002·Archives of Internal Medicine·Arthur L Weaver, Norman Gitlin

❮ Previous
Next ❯

Citations

Aug 18, 2009·Journal of Gastroenterology and Hepatology·Yun Jeong LimKi-Baik Hahm
Apr 18, 2012·Journal of Gastroenterology and Hepatology·Tomohisa TakagiToshikazu Yoshikawa
Jul 19, 2011·Journal of Clinical Biochemistry and Nutrition·Takashi KawaiShinya Goto
Nov 26, 2010·Journal of Clinical Biochemistry and Nutrition·Taiji AkamatsuEiji Tanaka
Mar 5, 2011·Journal of Clinical Biochemistry and Nutrition·Tomohisa TakagiToshikazu Yoshikawa
Feb 27, 2008·Journal of Clinical Biochemistry and Nutrition·Yuji NaitoToshikazu Yoshikawa
Dec 17, 2014·Journal of Gastroenterology·Hiroki EndoAtsushi Nakajima
Feb 20, 2009·Journal of Gastroenterology·Ingvar Bjarnason, Ken Takeuchi
Jul 2, 2009·Journal of Gastroenterology·Kazuhide HiguchiTetsuo Arakawa
Mar 1, 2012·Digestive Diseases and Sciences·Kyoichi AdachiYoshikazu Kinoshita
Aug 1, 2013·Clinical Journal of Gastroenterology·Takashi KawaiFuminori Moriyasu
Jan 16, 2008·Alimentary Pharmacology & Therapeutics·N D Yeomans, J Naesdal
Mar 21, 2009·Fundamental & Clinical Pharmacology·Omar M E Abdel SalamNabila S Hassan
Oct 16, 2016·Fundamental & Clinical Pharmacology·Sonia Goineau, Vincent Castagné
Jun 8, 2017·Scandinavian Journal of Gastroenterology·Ashish Srinivasan, Peter De Cruz
Apr 27, 2018·Journal of Digestive Diseases·Junseok ParkMoon Sung Lee
Jan 6, 2009·Current Opinion in Gastroenterology·Maggie Ham, Jonathan D Kaunitz
Dec 7, 2018·Journal of Neurogastroenterology and Motility·Rapat PittayanonVarocha Mahachai
Jun 10, 2010·Expert Review of Gastroenterology & Hepatology·Yuji Naito, Toshikazu Yoshikawa
Dec 31, 2015·The Cochrane Database of Systematic Reviews·Mariska Mg LeeflangChristina M Vandenbroucke-Grauls
Nov 22, 2012·Journal of Clinical Biochemistry and Nutrition·Kazuhiro MizukamiToshio Fujioka
Dec 2, 2017·Digestive Diseases and Sciences·Mohamed Hasif JaafarSanjiv Mahadeva
Dec 23, 2019·Journal of Gastroenterology·Toshio WatanabeFrancis K L Chan
Jan 1, 2015·Terapevticheskiĭ arkhiv·V I Simanenkov, S V Tikhonov

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SAS

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.