PMID: 2115930Jun 1, 1990Paper

Comparison of primary and secondary 26S rRNA structures in two Tetrahymena species: evidence for a strong evolutionary and structural constraint in expansion segments

Journal of Molecular Evolution
J EngbergT Higashinakagawa

Abstract

We have determined the nucleotide sequence of the 26S large subunit (LSU) rRNA genes for two Tetrahymena species, T. thermophila and T. pyriformis. The inferred rRNA sequences are presented in their most probable secondary structures based on compensatory mutations, energy, and conservation criteria. The majority of the nucleotide changes between the two Tetrahymena LSU rRNAs and the positions of a relatively large deletion and of the processing cleavage sites resulting in the generation of the hidden break are all located within the so-called divergent domains or expansion segments. These are regions within the common core of secondary structure where expansions have taken place during the evolution of the rRNA of higher eukaryotes. The dispensable nature of some of the expansion segments has been taken as evidence of their non-functionality. However, our data show that a considerable selective constraint has operated to preserve the secondary structure of these segments. Especially in the case of the D2 and D8 segments, the presence of a considerable number of compensatory base changes suggests that the secondary structure of these regions is of functional importance. Alternatively, these expansion segments may have maintaine...Continue Reading

References

Jul 3, 1978·European Journal of Biochemistry·W A EckertW W Franke
Jun 11, 1985·Nucleic Acids Research·N PedersenJ Engberg
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M L SoginJ H Gunderson
May 1, 1989·Journal of Molecular Evolution·R M PreparataD L Nanney
Jan 1, 1988·Progress in Biophysics and Molecular Biology·H A RauéW Musters
Jan 1, 1987·Journal of Molecular Evolution·C G Clark
Jan 1, 1988·Nucleic Acids Research·R R Gutell, G E Fox
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A BaroinA Adoutte
Sep 25, 1980·Journal of Molecular Biology·J EngbergR E Pearlman
Feb 14, 1980·Nature·M A Wild, R Sommer

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Citations

Jun 1, 1995·Journal of Molecular Evolution·J M Hancock
Sep 1, 1992·Journal of Helminthology·K A KarlstedtB J Wikgren
May 11, 1992·Nucleic Acids Research·R R GutellM W Gray
Jul 1, 1993·Nucleic Acids Research·R R GutellM N Schnare
Oct 6, 2000·Molecular Biology and Evolution·B BilloudJ S Deutsch
Jan 11, 2013·Viruses·Paul ShkilnyjGerald B Koudelka
Oct 20, 1991·Journal of Molecular Biology·A Fraile, F García-Arenal
Nov 17, 2007·The EMBO Journal·Mohammad M MohammadGeoffrey M Kapler
Nov 24, 2001·Molecular Biology and Evolution·A R Omilian, D J Taylor
Sep 17, 2019·The Journal of Eukaryotic Microbiology·Sun Young KimJoong Ki Choi
Apr 1, 1995·Molecular and Cellular Biology·G HougeS O Døskeland

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