Comparison of procalcitonin, a potentially new inflammatory biomarker of frailty, to interleukin-6 and C-reactive protein among older Chinese hospitalized patients

Aging Clinical and Experimental Research
Ying YangBirong Dong

Abstract

Procalcitonin (PCT) has predictive value for patients with infectious diseases, but has not been studied in frailty. The purpose of this study was to compare PCT to two other inflammatory biomarkers [interleukin-6 (IL-6)] and C-reactive protein (CRP) in their association with frailty among older hospitalized patients. Retrospective study of inpatients (June-December, 2016), who had all three biomarkers measured within 24 h of admission. Frailty was defined according to the Chinese version of a validated frailty scale. Due to the association of biomarkers with infection, we divided patients into "non-infected" (no pneumonia or other infections) and "pneumonia" (using standard criteria) groups. Of 435 patients (mean age 81.6 ± 8.6 years), 181 (41.6%) were designated the non-infected group and 254 (58.4%) the pneumonia group. Prevalence of frailty in the non-infected group was 32.0% (58/181) and frailty (univariate analysis) was associated with higher PCT and IL-6 levels but not CRP. Prevalence of frailty in the pneumonia group was 40.2% (102/254) and frailty was associated with all three biomarkers. In multivariable analysis adjusting for age, gender, smoking, alcohol use, hemoglobin, albumin, neutrophils and creatinine, PCT (not...Continue Reading

References

Feb 12, 2008·Journal of the American Medical Directors Association·Gabor Abellan van KanBruno Vellas
May 23, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Camille Chenevier-GobeauxYann-Erick Claessens
Jun 12, 2013·Tuberculosis and Respiratory Diseases·Ji Hye KimMin Ki Lee
Jun 25, 2013·Journal of the American Medical Directors Association·Martin MichaudFati Nourhashemi
Mar 19, 2014·Journal of the American Geriatrics Society·Theodore K MalmstromJohn E Morley
Aug 25, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Karen Bandeen-RocheJudith D Kasper
Nov 14, 2015·Age and Ageing·Josje D SchoufourHeleen M Evenhuis
Jun 9, 2016·Immunity & Ageing : I & a·Monika Puzianowska-KuźnickaMalgorzata Mossakowska
Sep 7, 2016·Ageing Research Reviews·Pinar SoysalNicola Veronese
Jan 25, 2017·BMC Medicine·Ramon SagerPhilipp Schuetz

❮ Previous
Next ❯

Citations

Mar 7, 2019·Aging Clinical and Experimental Research·Tomoyuki Kawada
Apr 19, 2019·Aging Clinical and Experimental Research·Ying YangBirong Dong
Oct 28, 2019·Aging Clinical and Experimental Research·Didier SchoevaerdtsGaetan Gavazzi
Sep 20, 2019·International Journal of Environmental Research and Public Health·Warathit SemmarathPornngarm Limtrakul Dejkriengkraikul
Nov 28, 2020·The Journal of Nutrition, Health & Aging·R Ramírez-VélezM Izquierdo
Apr 1, 2021·The Journal of Nutrition, Health & Aging·L MaP Chan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.