Comparison of prognostic nomograms based on different nodal staging systems in patients with resected gastric cancer

Journal of Cancer
Zi-Xian WangRui-Hua Xu

Abstract

Purpose: Previous studies addressing the optimal nodal staging system in patients with resected gastric cancer have shown inconsistent results, and the optimal system for development of prognostic nomograms remains unclear. In this study, we compared prognostic nomograms based on the metastatic lymph node (MLN) count, lymph node ratio (LNR), and log odds of metastatic lymph nodes (LODDS) to predict the 5-year overall survival in patients with resected gastric cancer. Methods: We analysed 15,320 patients with resected gastric cancer in the Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2010. Missing data were handled using multiple imputation. When assessed as a continuous covariate with restricted cubic splines, each MLN, LNR, and LODDS variable was incorporated into a nomogram with other significant prognosticators to predict the 5-year overall survival. A two-centre Chinese dataset (1,595 cases) was used as external validation data. Results: The discriminatory abilities of the MLN-, LNR-, and LODDS-based nomograms were comparable (concordance indices: 0.744, 0.741, and 0.744, respectively, in the SEER set, P > 0.152 for all pairwise comparisons; 0.715, 0.712, and 0.713, respectively, in the Chine...Continue Reading

Citations

Oct 26, 2018·World Journal of Gastroenterology : WJG·Ya-Fei ZhangYi-Ming Li
Mar 10, 2020·BioMed Research International·Cong-Kuan SongWeidong Hu
May 2, 2020·Journal of Clinical Medicine·Won Hyuk ChoiWoon Geon Shin
Dec 8, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Keyi WangBo Peng
Oct 28, 2020·Clinical and Translational Gastroenterology·Yuming JiangGuoxin Li
May 19, 2021·Journal of Cancer Research and Clinical Oncology·Jiebin XieXiaoting Wu

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