PMID: 12788184Jun 6, 2003Paper

Comparison of prognostic value of MRI and FIGO stage among patients with cervical carcinoma treated with radiotherapy

International Journal of Radiation Oncology, Biology, Physics
Takeshi KodairaKazuhiko Ogawa

Abstract

To compare the efficacy of MRI and FIGO stage, we performed retrospective multicenter analysis of patients with Stage II-III disease treated with radiation alone. From three institutions, 164 patients diagnosed with cervical carcinoma were entered into the study. The majority of this cohort received intracavitary brachytherapy combined with external beam radiotherapy (n = 161). Uni- and multivariate analyses were performed to identify the prognostic factors for overall survival (OAS), disease-free survival (DFS), pelvic control (PC), and distant metastasis-free survival (DMFS). The 5-year OAS, DFS, PC, and DMFS rates were 68.8%, 60.4%, 77.4%, and 71.7%, respectively. Using uni- and multivariate analyses, both large tumor size/volume and positive lymph node enlargement (LN) showed a significantly unfavorable influence on survival and local and/or distant failure (p < 0.05). Using these two prognostic factors, patients were divided into three subgroups; the 5-year DFS rates of patients with risk 0 (volume </=50 cc and negative LN), 1 (volume >50 cc or positive LN), and 2 (volume >50 cc and positive LN) were 72.9%, 53.3%, and 26.1%, respectively (p < 0.0001). Among patients with volume </=50 cc, disease stage proved to be a signif...Continue Reading

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Citations

Dec 7, 2006·American Journal of Clinical Oncology·Gilles CréhangeJean François Bosset
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Tormod EggenAnne Orbo
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Oct 3, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Chrishanthi RajasooriyarKailash Narayan

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