PMID: 3747499Jul 1, 1986Paper

Comparison of prosthetic graft materials as intracardiac right atrial patches

The Journal of Surgical Research
M H KadowakiS Glagov

Abstract

An experimental animal model was developed to study the fate of prosthetic graft materials within the heart. Autologous pericardium, bovine pericardium, polytetrafluoroethylene, woven Dacron, and autologous right atrium (control) patches were implanted into the wall at three sites on the right atrium in each of 10 dogs (six patches for each graft material). The atria were harvested 90-100 days later and histologic examination and quantitation of calcium were performed. Chronic inflammation and fibrosis were found in 29 of 30 grafts. Cartilage formed in 26 of 30 sites and was found both in the center and around the edges of the grafts. In addition to cartilage, bone including marrow elements formed in the two autologous materials at 4 of the 12 sites and in 1 of the Dacron graft sites. Calcium content was greater in the control and the bovine pericardial grafts than in the other graft materials (P = NS). The incidence and degree of inflammation, fibrosis, calcification and cartilage, and bone formation were similar in all materials. We conclude that the healing process of these intracardiac graft materials is a generalized phenomenon independent of the inherent properties of a specific graft material.

References

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Citations

Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·M H KadowakiS Glagov
Mar 21, 2008·Journal of Neurosurgery. Pediatrics·Andrew B FoyCorey Raffel
Nov 25, 2011·The Annals of Thoracic Surgery·Jacek J MollJadwiga A Moll
Mar 10, 2001·The Annals of Thoracic Surgery·R P Scott
Jun 1, 1993·Journal of Biomedical Materials Research·D SimionescuR Deac
Oct 1, 1996·Neurosurgery·J A Anson, E P Marchand
May 1, 2020·Frontiers in Cardiovascular Medicine·Andras P DurkoJolanda Kluin
Dec 1, 1991·Journal of Biomedical Materials Research·A SimionescuR Deac
Feb 29, 1988·Biochemical and Biophysical Research Communications·D SimionescuN A Kefalides

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