Comparison of protective effects of aspirin, D-penicillamine and vitamin E against high glucose-mediated toxicity in cultured endothelial cells

Biochimica Et Biophysica Acta
Jing ZhangNessar Ahmed

Abstract

This study compared the protective effects of three different anti-glycation compounds, aspirin, D-penicillamine and vitamin E, against high glucose and advanced glycation endproduct (AGE) mediated toxicity in cultured bovine aortic endothelial cells using two approaches. Their proliferation was assessed in culture in different concentrations of glucose (5.5-100 mmol/l) with and without these inhibitors. A monolayer of cultured endothelial cells was wounded and recovery at the wound site was measured following exposure to different concentrations of glucose with and without inhibitors. The ability of these compounds to protect cultured endothelial cells following exposure to bovine serum albumin-derived advanced glycation endproducts (BSA-AGE) was also studied. Addition of glucose to cultured endothelial cells inhibited their proliferation in a dose dependent manner. All three compounds protected against the anti-proliferative effects of high glucose, with vitamin E being the most effective. The migration of cultured endothelial cells following wounding was inhibited by increasing concentrations of glucose but was maintained in the presence of all three anti-glycation compounds with vitamin E, again giving the greatest protecti...Continue Reading

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Citations

Sep 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Warisa Amornrit, Rachana Santiyanont
Dec 27, 2015·Asian Pacific Journal of Tropical Medicine·Chiung-Tsun KuoHui-Yin Chen
Sep 11, 2007·Molecular Aspects of Medicine·Adelina Munteanu, Jean-Marc Zingg
Sep 12, 2006·Biochimica Et Biophysica Acta·John J Harding, Elena Ganea
Aug 18, 2006·Neurochemical Research·Vincenzo GiordanoMenotti Calvani

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