Comparison of proton therapy techniques for treatment of the whole brain as a component of craniospinal radiation

Radiation Oncology
Jeffrey DinhDavid R Grosshans

Abstract

For treatment of the entire cranium using passive scattering proton therapy (PSPT) compensators are often employed in order to reduce lens and cochlear exposure. We sought to assess the advantages and consequences of utilizing compensators for the treatment of the whole brain as a component of craniospinal radiation (CSI) with PSPT. Moreover, we evaluated the potential benefits of spot scanning beam delivery in comparison to PSPT. Planning computed tomography scans for 50 consecutive CSI patients were utilized to generate passive scattering proton therapy treatment plans with and without Lucite compensators (PSW and PSWO respectively). A subset of 10 patients was randomly chosen to generate scanning beam treatment plans for comparison. All plans were generated using an Eclipse treatment planning system and were prescribed to a dose of 36 Gy(RBE), delivered in 20 fractions, to the whole brain PTV. Plans were normalized to ensure equal whole brain target coverage. Dosimetric data was compiled and statistical analyses performed using a two-tailed Student's t-test with Bonferroni corrections to account for multiple comparisons. Whole brain target coverage was comparable between all methods. However, cribriform plate coverage was su...Continue Reading

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Citations

Jun 20, 2017·Pediatric Blood & Cancer·Damien C WeberBarbara Bachtiary
Nov 22, 2014·The Cancer Journal·Susan L McGovernAnita Mahajan
Jul 7, 2015·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·S A GoryaynovL V Shishkina

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Software Mentioned

MFO
Eclipse
IMPT

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