Comparison of pterygomaxillary dysjunction with tuberosity separation in isolated Le Fort I osteotomies: a prospective, multi-centre, triple-blind, randomized controlled trial

International Journal of Oral and Maxillofacial Surgery
A ChristabelVinod Narayanan

Abstract

The aim of this trial was to compare two techniques of maxillary dysjunction, with 10mg/kg tranexamic acid as an adjuvant, in isolated non-segmented Le Fort I procedures. Two hundred patients were randomized to one of four groups: group A, pterygomaxillary dysjunction+saline; group B, tuberosity separation+saline; group C, pterygomaxillary dysjunction+tranexamic acid; and group D, tuberosity separation+tranexamic acid. Primary outcome measures were intraoperative blood loss and operating time, while the secondary outcome measures were surgical field assessment, need for blood transfusion, and duration of hospitalization. The data were analyzed using one-way analysis of variance (SPSS v. 17.0), and the level of significance was set at P<0.05. Results revealed that group D (tuberosity separation+tranexamic acid) had the least blood loss (mean 172 ml) and shortest operating times (mean 49 min), with the best surgical field. This group also exhibited the lowest drop in postoperative haemoglobin concentration (Hbgm/dl) and packed cell volume (PCV). Five patients, all in group A, required a blood transfusion and had an extra 24h of hospitalization. This trial revealed that the tuberosity separation technique with the use of tranexami...Continue Reading

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Citations

Sep 14, 2018·Plastic and Reconstructive Surgery·Sadek MowakketAchilleas Thoma
May 11, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Dörte OhrmannPhilip Kuo-Ting Chen
Oct 20, 2020·Journal of Maxillofacial and Oral Surgery·Manikandhan RamanathanHermann F Sailer
Mar 5, 2021·Facial Plastic Surgery & Aesthetic Medicine·Rao FuRu-Lin Huang

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