PMID: 58939Mar 1, 1976

Comparison of radio-immunoassay and lymphocytotoxicity inhibition techniques for the determination of beta2 microglobulin

Journal of Immunological Methods
C Vincent, J P Revillard

Abstract

Rabbit anti-human beta2 microglobulin antisera can lyse human lymphocytes in the presence of rabbit complement. Inhibition of the lymphocytotoxic reaction by highly purified beta2m was applied to the measurement of beta2m concentration in biological fluids. Parallel determinations were also performed using a radioimmunoassay. Lymphocytotoxicity inhibition is simple and more sensitive than radial immunodiffusion but less sensitive than the radioimmunoassay. beta2m was measured by these two techniques in serum and urine from normal individuals, uremic or transplanted patients.

References

Jul 1, 1975·Cellular Immunology·C VincentJ P Revillard
Dec 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·P E EvrinI Berggård
Jan 1, 1973·Nephron·L WibellI Berggård
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P CresswellR T Kubo
May 31, 1974·Nature·L UstbergP A Peterson
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·K NakamuroD Pressman
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonG M Edelman
Dec 28, 1973·Science·M L BachM D Poulik
Jul 1, 1974·Transplantation·M RobertJ P Revillard
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Feb 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·P E Evrin, L Wibell

Citations

Feb 5, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·S BeorchiaC Trepo
Jan 1, 1981·Journal of Immunological Methods·R CurryR P Messner
Jun 1, 1980·Molecular Immunology·C Vincent, J P Revillard
Aug 1, 1983·Molecular Immunology·C Vincent, J P Revillard
Mar 1, 1997·Journal of Affective Disorders·H CoşkunolI Tuğlulaŕ
Apr 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·J P Allain
Aug 1, 1983·European Journal of Cancer & Clinical Oncology·R BatailleJ Sany
Jul 1, 1982·Clinical Immunology and Immunopathology·J P LamelinJ P Revillard
Jan 1, 1982·Clinical and Experimental Dermatology·C Scully
Jun 1, 1980·Vox Sanguinis·J P Revillard
Aug 1, 1984·Kidney International·C GauthierM V Pellet
Jan 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M OnjiH C Thomas
Jun 1, 1982·Journal of Dental Research·C Scully, P Boyle
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PignatelliH C Thomas
May 1, 1983·International Journal of Peptide and Protein Research·M ChauvetJ P Revillard

Related Concepts

Beta(1)CA Globulin
Beta-2 Microglobulin
Microcytotoxicity Test
Radioimmunoassay

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.