PMID: 15362487Sep 15, 2004Paper

Comparison of raloxifene and atorvastatin effects on serum lipids composition of healthy post-menopausal women

Molecular and Cellular Biochemistry
C PiperiA Kalofoutis

Abstract

The aim of this study was to evaluate the effects of the selective oestrogen receptor modulator, raloxifene, and those of statin, atorvastatin, in reducing the cardiovascular risks associated with the post-menopausal status. A detailed study of serum lipid concentrations was performed in four groups of post-menopausal women receiving either placebo, raloxifene or atorvastatin alone or their combination for the period of three months. Group A (raloxifene) showed significant decrease in total cholesterol levels (P < 0.05) and an increase in phospholipids concentration (P < 0.05), followed by a marked reduction in low-density lipoprotein cholesterol (LDL-C) levels (P < 0.01) and ApoB amounts (P < 0.001). Additionally, ApoA-I concentration was significantly increased (P < 0.01). Group B (atorvastatin) presented decreased cholesterol (P < 0.05) and triglycerides levels (P < 0.01), followed by elevated high-density lipoprotein cholesterol (HDL-C) concentration (P < 0.05) and low LDL-C amounts (P < 0.001). ApoA-I was significantly increased (P < 0.001) whereas ApoB was reduced (P < 0.001). The combined treatment in Group C (raloxifene and atorvastatin) showed significant changes in the majority of serum lipids. In particular, total ch...Continue Reading

Citations

Feb 17, 2005·American Journal of Physiology. Renal Physiology·Fung Ping LeungYu Huang
Dec 17, 2009·Archives of Gynecology and Obstetrics·Efser Oztas, Gulay Kurtay
Jan 23, 2021·The Cochrane Database of Systematic Reviews·Muhammad Ismail ShawishJames M Wright

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