Comparison of random-effects meta-analysis models for the relative risk in the case of rare events: A simulation study.

Biometrical Journal. Biometrische Zeitschrift
Marie BeisemannHeinz Holling

Abstract

Pooling the relative risk (RR) across studies investigating rare events, for example, adverse events, via meta-analytical methods still presents a challenge to researchers. The main reason for this is the high probability of observing no events in treatment or control group or both, resulting in an undefined log RR (the basis of standard meta-analysis). Other technical challenges ensue, for example, the violation of normality assumptions, or bias due to exclusion of studies and application of continuity corrections, leading to poor performance of standard approaches. In the present simulation study, we compared three recently proposed alternative models (random-effects [RE] Poisson regression, RE zero-inflated Poisson [ZIP] regression, binomial regression) to the standard methods in conjunction with different continuity corrections and to different versions of beta-binomial regression. Based on our investigation of the models' performance in 162 different simulation settings informed by meta-analyses from the Cochrane database and distinguished by different underlying true effects, degrees of between-study heterogeneity, numbers of primary studies, group size ratios, and baseline risks, we recommend the use of the RE Poisson re...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Dec 7, 2000·Journal of Clinical Epidemiology·J L Tang
Apr 30, 2004·Statistics in Medicine·Michael J SweetingPaul C Lambert
Jul 14, 2004·BMC Medical Research Methodology·James P GuevaraFredric M Wolf
Apr 6, 2006·Statistics in Medicine·Michael J BradburnA Russell Localio
Mar 6, 2009·The American Journal of Gastroenterology·F KeusC J H M van Laarhoven
May 26, 2010·Statistics in Medicine·Nan LairdXiao Ding
Jul 14, 2010·Statistics in Medicine·Tianxi CaiLouise Ryan
Jan 6, 2012·Statistical Methods in Medical Research·Peter W Lane
May 5, 2012·BMC Medical Research Methodology·Fiona C WarrenAlex J Sutton
Jun 5, 2013·Journal of the American Statistical Association·Dulal K BhaumikRobert D Gibbons
Mar 1, 2012·Research Synthesis Methods·Jonathan J ShusterJay S Skyler
Jan 27, 2015·Journal of the American Statistical Association·Dungang LiuMinge Xie
Apr 29, 2015·Biometrical Journal. Biometrische Zeitschrift·Dankmar BöhningAlan Kimber
May 1, 2015·BMC Medical Research Methodology·Matthew J SpittalLyle C Gurrin
Jan 6, 2016·Statistics in Medicine·Jonathan J Shuster, Michael A Walker
Apr 30, 2016·Statistics in Biopharmaceutical Research·Ou BaiXinlei Wang
Sep 14, 2016·JAMA : the Journal of the American Medical Association·Lars G HemkensMatthias Briel
Oct 19, 2016·Biometrical Journal. Biometrische Zeitschrift·Tim FriedeBeat Neuenschwander
Apr 14, 2018·Evidence-based Mental Health·Orestis Efthimiou
Apr 27, 2018·Contemporary Clinical Trials Communications·Konstantinos PaterasKit C B Roes
Jul 6, 2018·BMC Medical Research Methodology·Ilyas Bakbergenuly, Elena Kulinskaya
Jul 20, 2018·Contemporary Clinical Trials Communications·Lie LiXinlei Wang
Aug 1, 2018·Biometrical Journal. Biometrische Zeitschrift·Dan Jackson, Ian R White
Jul 28, 2019·Research Synthesis Methods·Burak Kürsad GünhanTim Friede

❮ Previous
Next ❯

Citations

Nov 10, 2020·Biometrical Journal. Biometrische Zeitschrift·Yuta HamaguchiToshi A Furukawa
Apr 4, 2021·International Journal of Environmental Research and Public Health·Fahad M Al AmerLifeng Lin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Colin G WeaverRobert R Quinn
Statistical Methods in Medical Research
Gwangsu Kim, Youngjo Lee
© 2022 Meta ULC. All rights reserved