Comparison of red blood cell hematology among normal, alpha-thalassemia-1 trait, and hemoglobin Bart's fetuses at mid-pregnancy

American Journal of Hematology
Kasemsri SrisupunditT Tongsong


The objective of this study was to compare red blood cell indices among normal, alpha-thalassemia-1 trait, and hemoglobin (Hb) Bart's fetuses at mid-pregnancy. A total of 87 pregnancies (88 fetuses) at risk of homozygous alpha-thalassemia-1, who underwent cordocentesis including the measurement of Hb level and red blood cell indices of fetuses at 18-22 weeks of gestation at Maharaj Nakorn Chiang Mai Hospital, were recruited into this study. The final outcome was based on the fetal DNA analysis using PCR technique for SEA type alpha-thalassemia-1. Fetuses were divided into three groups: normal, alpha-thalassemia-1 trait, and homozygous alpha-thalassemia-1 (Hb Bart's disease). The mean gestational age of the 87 pregnant women recruited into the study was 18.7 +/- 0.8 weeks. According to the DNA analysis, the incidence of Hb Bart's disease, alpha-thalassemia-1 trait, and normal fetuses were 29.5%, 45.5%, and 25%, respectively. The mean Hb level, mean corpuscular volume, mean corpuscular Hb, and mean cell Hb concentration were significantly different in all three groups of fetuses. Moreover, these differences were also found among fetuses with the alpha-thalassemia-1 trait and those that were normal. Ninety-two percent of fetuses w...Continue Reading


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Jul 28, 2013·Journal of Pediatric Hematology/oncology·Kasemsri SrisupunditT Tongsong
Dec 5, 2009·Prenatal Diagnosis·Sherry S Y HoMahesh Choolani

Related Concepts

Hemoglobin Bart's
Mean Corpuscular Hemoglobin Concentration Determination
Abnormal Hemoglobins
Genetic Carriers
Pregnancy Trimester, Second
Antenatal Screening Procedures
Incidence Studies
Nested Case-Control Studies
Nested Polymerase Chain Reaction

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