Comparison of regional lung perfusion response on longitudinal MAA SPECT/CT in lung cancer patients treated with and without functional tissue-avoidance radiation therapy.

The British Journal of Radiology
Hannah Mary T ThomasStephen R Bowen

Abstract

The effect of functional lung avoidance planning on radiation dose-dependent changes in regional lung perfusion is unknown. We characterized dose-perfusion response on longitudinal perfusion single photon emission computed tomography (SPECT)/CT in two cohorts of lung cancer patients treated with and without functional lung avoidance techniques. The study included 28 primary lung cancer patients: 20 from interventional (NCT02773238) (FLARE-RT) and eight from observational (NCT01982123) (LUNG-RT) clinical trials. FLARE-RT treatment plans included perfused lung dose constraints while LUNG-RT plans adhered to clinical standards. Pre- and 3 month post-treatment macro-aggregated albumin (MAA) SPECT/CT scans were rigidly co-registered to planning four-dimensional CT scans. Tumour-subtracted lung dose was converted to EQD2 and sorted into 5 Gy bins. Mean dose and percent change between pre/post-RT MAA-SPECT uptake (%ΔPERF), normalized to total tumour-subtracted lung uptake, were calculated in each binned dose region. Perfusion frequency histograms of pre/post-RT MAA-SPECT were analyzed. Dose-response data were parameterized by sigmoid logistic functions to estimate maximum perfusion increase (%ΔPERFmaxincrease), maximum perfusion decre...Continue Reading

References

Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·M GaripagaogluL B Marks
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·Y SeppenwooldeJ V Lebesque
Oct 21, 2000·Seminars in Radiation Oncology·Z VujaskovicM S Anscher
Jan 5, 2002·International Journal of Radiation Oncology, Biology, Physics·Roxanne T WoelLawrence B Marks
Jul 4, 2002·International Journal of Radiation Oncology, Biology, Physics·Yvette SeppenwooldeKazuo Miyasaka
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Ramesh GopalGeorge Starkschall
Apr 28, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·George RodriguesJake Van Dyk
Oct 7, 2004·International Journal of Radiation Oncology, Biology, Physics·Yvette SeppenwooldeJoos V Lebesque
Jun 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Vivek Mehta
Nov 9, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Judith A ChristianMichael Brada
Feb 10, 2006·Physics in Medicine and Biology·Thomas GuerreroRitsuko Komaki
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andreas K BuckAlexander Drzezga
Dec 17, 2008·International Journal of Radiation Oncology, Biology, Physics·Jinli MaLawrence B Marks
Jul 28, 2009·International Journal of Radiation Oncology, Biology, Physics·Junan ZhangLawrence B Marks
Mar 17, 2010·International Journal of Radiation Oncology, Biology, Physics·Gerben R BorstJan-Jakob Sonke
May 17, 2011·Biochemistry. Biokhimii︠a︡·I R Grin, D O Zharkov
Dec 27, 2011·International Journal of Radiation Oncology, Biology, Physics·Shuanghu Tiger YuanFeng-Ming Spring Kong
Jun 12, 2012·International Journal of Radiation Oncology, Biology, Physics·David A PalmaGeorge Rodrigues
Jul 18, 2012·Polish journal of radiology·Grzegorz Bauman, Monika Eichinger
Aug 25, 2012·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·S J AmentM Schreckenberger
Mar 12, 2013·International Journal of Radiation Oncology, Biology, Physics·Yevgeniy VinogradskiyMary K Martel
Jan 13, 2015·Technology in Cancer Research & Treatment·Shankar SivaMichael S Hofman
Mar 17, 2015·Seminars in Radiation Oncology·Feng-Ming Spring Kong, Shulian Wang
Apr 1, 2015·Practical Radiation Oncology·Michael VelecKristy K Brock
Dec 22, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tokihiro YamamotoMegan Daly
Jun 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Yevgeniy VinogradskiyMoyed Miften
Oct 12, 2016·AJR. American Journal of Roentgenology·Saeed ElojeimyHubert Vesselle
Mar 4, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Gurleen DhamiStephen R Bowen
May 10, 2017·Clinics in Chest Medicine·Trevor J BledsoeRoy H Decker
Sep 3, 2017·International Journal of Radiation Oncology, Biology, Physics·Daniel F PolanKristy K Brock
Dec 6, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Katherina P FarrCai Grau
Aug 8, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicholas W BucknellShankar Siva
Aug 16, 2018·International Journal of Radiation Oncology, Biology, Physics·Howard J LeeStephen R Bowen
Aug 16, 2018·International Journal of Radiation Oncology, Biology, Physics·Daniel Rocky OwenMartha M Matuszak

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