Abstract
We compared relapse-free survival (RFS) in gastric neuroendocrine carcinoma (WHO grade 3) and gastric carcinoma (GC). This is one of very few studies that compare the prognosis of poorly differentiated neuroendocrine carcinoma (WHO grade 3, G3 NEC) with that of GC. Between 1996 and 2014, 63 patients were diagnosed with G3 NEC of the stomach and 56 with gastric neuroendocrine tumors (NETs) with GC at Asan Medical Center in Seoul, Korea. We also randomly selected 762 patients diagnosed with GC between 1999 and 2008. Patients with G3 NEC tumors that invaded the muscularis propria or shallower had poorer RFS than those with GC of the same type, while G3 NEC that invaded the subserosa or deeper had similar RFS to GC of that type. Patients diagnosed with G3 NEC with N0 or N2 had poorer RFS than the corresponding patients with GC, while those who had G3 NEC with N1 or N3 had similar RFS to the corresponding patients with GC. G3 NEC patients had poorer RFS than well-differentiated, moderately differentiated and poorly differentiated GC patients, while G3 NEC patients had similar RFS to that of those with signet ring cell carcinoma (SRC). In addition, patients with G3 NEC of stages I or IIa had poorer RFS than those with corresponding G...Continue Reading
References
Feb 25, 1999·Gastroenterology·G RindiE Solcia
May 2, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hiroyuki MatsubayashiMitsuya Iwafuchi
Feb 6, 2003·Cancer·Irvin M ModlinMark Kidd
Dec 23, 2003·The American Journal of Gastroenterology·Irvin M ModlinMark Kidd
Jan 13, 2004·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ken NishikuraYoichi Ajioka
Jul 25, 2006·The American Journal of Surgical Pathology·Shi-Xu JiangIsao Okayasu
Sep 13, 2006·Virchows Archiv : an International Journal of Pathology·G RindiUNKNOWN European Neuroendocrine Tumor Society (ENETS)
Feb 29, 2008·The British Journal of Surgery·L FischerM W Büchler
May 29, 2008·Cancer·Ulrich-Frank PapeBertram Wiedenmann
Aug 22, 2008·Human Pathology·Stefano La RosaEnrico Solcia
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sara EkebladBarbro Eriksson
Dec 9, 2008·Neuroendocrinology·Günter KlöppelUNKNOWN European Neuroendocrine Tumor Society
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 23, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Aldo ScarpaMassimo Falconi
May 3, 2011·Human Pathology·Stefano La RosaEnrico Solcia
Jan 19, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Takeshi KubotaToshiharu Yamaguchi
Feb 11, 2012·Journal of Gastric Cancer·Jang Jin KimSang-Uk Han
Jun 14, 2013·The American Journal of Surgical Pathology·Michihiro IshidaRyoji Kushima
Jan 1, 2012·Cancers·Stefano La RosaCarlo Capella
Apr 5, 2014·Endocrine Pathology·G RindiF Inzani
Sep 10, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ji Y ParkYoon-Koo Kang
Citations
Feb 7, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ping HuQiyun Tang
Nov 14, 2019·Annals of Surgical Oncology·Elettra MerolaMarianne E Pavel
Apr 18, 2019·Journal of Oncology·Hu RenDong-Bing Zhao
Aug 17, 2020·Current Gastroenterology Reports·Mengyuan LiuRasa Zarnegar
Nov 21, 2017·Internal Medicine·Yoshiharu Motoo
Nov 4, 2020·The American Surgeon·Nam Young ChoiBeom Su Kim
Nov 3, 2020·Translational Oncology·Yi ZouYing Yuan
Jun 18, 2021·World Journal of Gastroenterology : WJG·Deng HanHuang-Ying Tan
Jul 28, 2021·JAMA Network Open·Jianxian LinJianwei Xie
Jul 6, 2019·Case Reports in Oncology·Ester OnedaAlberto Zaniboni