PMID: 9552780Apr 29, 1998Paper

Comparison of remifentanil and propofol infusions for sedation during regional anesthesia

Regional Anesthesia and Pain Medicine
M H LauwersF Camu

Abstract

Patients treated with regional anesthesia often require concomitant medication for comfort and sedation. Propofol is widely used for this purpose. Remifentanil, a new ultra-short-acting opioid, exhibits at low doses distinct sedative properties that may be useful for supplementation of regional anesthesia. This study compared the effectiveness of remifentanil and propofol infusions for providing sedation during regional block placement and surgery. In an open, prospective trial, 28 patients were randomly allocated to receive continuous infusions of remifentanil (6 microg/kg/h) or propofol (3 mg/kg/h) for sedation during spinal or axillary regional anesthesia. Infusion rates were titrated to maintain a sedation level > or = 2 as assessed with the Observer's Assessment of Alertness Scale. Vital signs were measured continuously, during and for 2 hours after ending study drug infusion. Similar scores for comfort and sedation were obtained in both groups during placement of the regional block and during surgery. Degree of sedation correlated with drug infusion rate of remifentanil (P < .002) but not for propofol. Respiratory rate decreased in the remifentanil group in absence of surgery (P < .05). Mean arterial pressure and heart ra...Continue Reading

Citations

Jan 24, 2007·European Journal of Anaesthesiology·I CoskunerK Elcicek
Jun 14, 2003·European Journal of Anaesthesiology·A T MoermanE P Mortier
Jun 27, 2001·Journal of Neurosurgical Anesthesiology·H BerkenstadtZ Ram
Apr 12, 2005·Drugs·Chester C Buckenmaier, Lisa L Bleckner
Jan 18, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Gabriel F LacombeDaniel A Haas
Aug 7, 2012·Anaesthesia·R Sneyd
Sep 22, 2006·Acta Anaesthesiologica Scandinavica·Z N AkcaboyN Gogus
Feb 4, 2003·Anaesthesia·N HarperD Hume

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