Comparison of remission criteria in a tumour necrosis factor inhibitor treated rheumatoid arthritis longitudinal cohort: patient global health is a confounder

Arthritis Research & Therapy
Emese BaloghDouglas J Veale

Abstract

Our objectives were to assess the frequency and sustainability of American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) and Disease Activity Score (DAS)28(4v)-C-reactive protein (CRP) remission 12 months after the initiation of tumour necrosis factor inhibitor (TNFi) therapy in a rheumatoid arthritis (RA) cohort. Data were collected of 273 biologic naive RA patients at baseline, then 3, 6 and 12 months post-TNFi therapy. Remission status was calculated using DAS28(4v)-CRP <2.6 and ACR/EULAR Boolean criteria. Response was scored using EULAR criteria. Mean (range) patient age was 59.9 (7.2-85.4) years with disease duration of 13.4 (1.0-52.0) years. Responder status maintained from 3-12 months (86%, 82.4%), laboratory/clinical parameters (erythrocyte sedimentation rate (ESR), CRP, patient global health (PGH), DAS28(4v)-CRP) also showed sustained improvement (P < 0.05). DAS28 remission was reached by 102 subjects at 1 year, 27 patients were in Boolean remission, but 75 missed it from the DAS28 remission group. Patients in remission were younger (P = 0.041) with lower baseline tender joint count (TJC)28 and PGH than those not in remission (P = 0.001, P = 0.047). DAS28 remission patients were older (P = 0....Continue Reading

References

Oct 20, 1998·Arthritis and Rheumatism·A M van GestelP L van Riel
Apr 16, 2003·Annals of the Rheumatic Diseases·H J M VrijhoefSj Van der Linden
Dec 8, 2009·Rheumatic Diseases Clinics of North America·Jaap Fransen, Piet L C M van Riel
Mar 11, 2010·Annals of the Rheumatic Diseases·Josef S SmolenUNKNOWN T2T Expert Committee
Mar 20, 2010·Annals of the Rheumatic Diseases·Monika SchoelsJosef S Smolen
Nov 10, 2011·British Journal of Nursing : BJN·Jill Firth
Nov 10, 2011·British Journal of Nursing : BJN·Jill Firth, Sarah Critchley
Nov 30, 2011·International Journal of Psychiatry in Clinical Practice·Geartsje BoonstraRené S Kahn
Jan 17, 2012·The Journal of Rheumatology·Margaret H Y MaDavid L Scott
Mar 21, 2012·Arthritis Research & Therapy·Femke H M PrinceDaniel H Solomon
Apr 4, 2012·Annals of the Rheumatic Diseases·Désirée van der Heijde
Oct 24, 2012·Clinical Rheumatology·Yasuhiko HirabayashiUNKNOWN Michinoku Tocilizumab Study Group

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Citations

Jul 3, 2015·EBioMedicine·Ursula Fearon, Douglas J Veale
Oct 30, 2016·Arthritis Research & Therapy·Elena NikiphorouLaure Gossec
Jul 14, 2017·Nature Reviews. Rheumatology·Carl OrrSander W Tas
Feb 28, 2019·International Journal of Rheumatic Diseases·Chak Sing LauSwan Sim Yeap
Jun 7, 2019·JBI Database of Systematic Reviews and Implementation Reports·Eduardo J F SantosMaria Barbieri-Figueiredo
Dec 21, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·William S Wilke
Sep 2, 2017·Rheumatology·Ricardo J O FerreiraUNKNOWN CoimbRA investigators, RAID investigators and COMEDRA investigators
Oct 10, 2020·International Journal of Rheumatic Diseases·Yirong XiangUNKNOWN Chinese Registry of Rheumatoid Arthritis co-authors
Jan 15, 2021·Arthritis Research & Therapy·Kieran MurrayDouglas J Veale
Dec 11, 2020·Arthritis Research & Therapy·Marta Novella-NavarroAlejandro Balsa
Jun 8, 2021·Therapeutic Advances in Musculoskeletal Disease·Serena BugattiCarlomaurizio Montecucco

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Methods Mentioned

BETA
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SPSS

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