PMID: 2987127May 1, 1985Paper

Comparison of renin and converting enzyme inhibition in sodium-deficient dogs

Hypertension
E H BlaineJ Boger

Abstract

While renin is a highly specific protease, converting enzyme has at least two principal substrates, angiotensin I and bradykinin. Changes in the rate of formation of angiotensin II or degradation of bradykinin can influence the hypotensive action of angiotensin converting enzyme inhibitors. The present study was designed to determine if there were differences in the maximal blood pressure reduction in Na-deficient dogs after angiotensin converting enzyme or renin inhibitor treatment. Five conscious dogs received 0.1, 0.5, and 1.0 mg/kg of i.v. enalaprilat, a potent angiotensin converting enzyme inhibitor, which reduced blood pressure to 75 +/- 4, 71 +/- 5, and 71 +/- 5 mm Hg. Plasma immunoreactive angiotensin II levels were reduced in a dose-related fashion to 35% of control level at the highest dose. Infusion of a maximally effective dose of a statine-containing renin inhibitor (SCRIP) with the high dose of enalaprilat produced no further fall in blood pressure (68 +/- 7 mm Hg), but immunoreactive angiotensin II levels fell to essentially zero in four of five dogs. The order of drug administration was reversed in another experiment in a group of nine dogs in which SCRIP reduced plasma immunoreactive angiotensin II to 25% of co...Continue Reading

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Citations

Sep 1, 1994·Journal of Clinical Pharmacology·W H FrishmanC Dike
Oct 1, 1995·Cardiovascular Drugs and Therapy·H D Kleinert
Sep 15, 1988·Klinische Wochenschrift·K G Hofbauer, J M Wood
Feb 1, 1995·Pharmacology & Therapeutics·J R CockcroftD J Webb
Jan 1, 1994·Pharmacology & Therapeutics·J M WoodJ Maibaum
May 31, 2002·Autonomic Neuroscience : Basic & Clinical·Jacques R RouleauJohn G Kingma
Jul 1, 1990·Journal of Pharmacological Methods·D T PalsS J Couch
May 1, 1996·American Heart Journal·C Lin, W H Frishman
Jan 1, 1987·Journal of Enzyme Inhibition·J M WoodK G Hofbauer
Jul 1, 1990·Hypertension·P CorvolJ Ménard
Mar 1, 1992·Hypertension·M VéniantW Fischli
Jun 1, 1989·Hypertension·P F MentoB M Wilkes
Apr 1, 1990·Medicinal Research Reviews·W J Greenlee

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