Comparison of responses evoked by mild indirect cooling and by sound in the forearm vasculature in patients with homozygous sickle cell disease and in normal subjects

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
J S MohanG R Serjeant

Abstract

In normal individuals, novel or noxious stimuli commonly evoke the pattern of the alerting or defence response which includes cutaneous vasoconstriction, but vasodilatation in forearm skeletal muscle. We have compared cardiovascular responses evoked by sound and by indirect cooling in 60 patients with homozygous sickle cell (SS) disease and in 30 control subjects with normal haemoglobin genotype (AA). A sound of 90 dB, 1 kHz for 30s evoked an increase in hand and forearm cutaneous vascular resistance (HCVR and FCVR) in SS patients and an increase in HCVR in AA subjects, as assessed from Doppler flowmetry. Meanwhile, a decrease in forearm vascular resistance (FVR) assessed by venous occlusion plethysmography, occurred in 14 out of 30 AA subjects and 25 out of 60 SS patients, indicating vasodilatation in forearm muscle; an increase in FVR occurred in the remainder. The proportions of SS patients and AA subjects who showed an increase in FVR (53% vs 57%) were not significantly different. Cooling increased HCVR and FCVR in SS patients and increased FCVR in AA subjects; a decrease in FVR indicating vasodilatation, occurred in 12 out of 30 AA subjects, but in only 10 out of 60 SS patients. The proportion of SS patients who showed an ...Continue Reading

References

Oct 1, 1990·Journal of Clinical Pathology·G R Serjeant, R M Chalmers
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·A W Zbrozyna, D M Westwood
Dec 1, 1967·Annals of Internal Medicine·S Charache, D L Page
Jun 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J S MohanG R Serjeant
Jul 1, 1994·British Journal of Haematology·G R SerjeantP W Thomas
Apr 1, 1994·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J Mohan, J M Marshall
Apr 1, 1994·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J Mohan, J M Marshall

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Citations

Apr 1, 1994·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J Mohan, J M Marshall
Sep 9, 2005·International Journal of Hematology·Birol GuvencAyberk Besena
Jun 26, 2010·The Journal of Emergency Medicine·Alexander L RogovikRan D Goldman
Aug 2, 2008·Pediatric Pulmonology·Robert C StrunkMichael R DeBaun
Aug 27, 2004·Anesthesiology·Paul G Firth, C Alvin Head
Oct 18, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Danelle M OkesonRob L Coke
Jul 10, 2009·Neuropsychological Rehabilitation·Margaret C Høegh, Steffen-Malik Høegh
Dec 30, 2014·Medicine·Armand Mekontso DessapSandrine Katsahian
Sep 26, 2017·Microvascular Research·W BirkhoffJ Burggraaf

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