Comparison of Risk Factor Profiles for Primary Open-Angle Glaucoma Subtypes Defined by Pattern of Visual Field Loss: A Prospective Study

Investigative Ophthalmology & Visual Science
Jae H KangLouis R Pasquale

Abstract

We explored whether risk factor associations differed by primary open-angle glaucoma (POAG) subtypes defined by visual field (VF) loss pattern (i.e., paracentral or peripheral). We included 77,157 women in the Nurses' Health Study (NHS) and 42,773 men in the Health Professionals Follow-up Study (HPFS 1986-2010), and incident medical record confirmed cases of paracentral (n = 440) and peripheral (n = 865) POAG subtypes. We evaluated African heritage, glaucoma family history, body mass index (BMI), mean arterial blood pressure, diabetes mellitus, physical activity, smoking, caffeine intake, and alcohol intake. We used competing risk Cox regression analyses modeling age as the metameter and stratified by age, cohort, and event type. We sequentially identified factors with the least significant differences in associations with POAG subtypes ("stepwise down" approach with P for heterogeneity [P-het] < 0.10 as threshold). Body mass index was more inversely associated with the POAG paracentral VF loss subtype than the peripheral VF loss subtype (per 10 kg/m2; hazard ratio [HR] = 0.67 [95% confidence interval (CI): 0.52, 0.86] versus HR = 0.93 [95% CI: 0.78, 1.10]; P-het = 0.03) as was smoking (per 10 pack-years; HR = 0.92 [95% CI: 0.8...Continue Reading

Citations

Dec 23, 2015·International Journal of Molecular Sciences·Khaled Abu-AmeroKakarla V Chalam
Oct 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Idan HechtZvia Burgansky-Eliash
Oct 22, 2016·Current Diabetes Reports·Brian J SongLouis R Pasquale
Mar 15, 2018·Acta Ophthalmologica·Jae H KangLouis R Pasquale
Feb 17, 2018·Current Eye Research·Ewa Kosior-JareckaTomasz Żarnowski
Dec 16, 2017·The British Journal of Ophthalmology·Connie M WuAnne L Coleman
Dec 19, 2018·Current Opinion in Ophthalmology·Claudio I PerezShan Lin
Jan 11, 2020·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Rajiv KhandekarDeepak P Edward
Aug 18, 2017·Journal of Ophthalmology·Ewa Kosior-JareckaTomasz Żarnowski
Jun 18, 2017·Clinical & Experimental Ophthalmology·Nathalie ChiamEranga N Vithana
Nov 28, 2020·Translational Vision Science & Technology·Bettina TengMengyu Wang

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