Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate.

JAMA : the Journal of the American Medical Association
Kunihiro MatsushitaChronic Kidney Disease Prognosis Consortium

Abstract

The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation more accurately estimates glomerular filtration rate (GFR) than the Modification of Diet in Renal Disease (MDRD) Study equation using the same variables, especially at higher GFR, but definitive evidence of its risk implications in diverse settings is lacking. To evaluate risk implications of estimated GFR using the CKD-EPI equation compared with the MDRD Study equation in populations with a broad range of demographic and clinical characteristics. A meta-analysis of data from 1.1 million adults (aged ≥ 18 years) from 25 general population cohorts, 7 high-risk cohorts (of vascular disease), and 13 CKD cohorts. Data transfer and analyses were conducted between March 2011 and March 2012. All-cause mortality (84,482 deaths from 40 cohorts), cardiovascular mortality (22,176 events from 28 cohorts), and end-stage renal disease (ESRD) (7644 events from 21 cohorts) during 9.4 million person-years of follow-up; the median of mean follow-up time across cohorts was 7.4 years (interquartile range, 4.2-10.5 years). Estimated GFR was classified into 6 categories (≥90, 60-89, 45-59, 30-44, 15-29, and <15 mL/min/1.73 m(2)) by both equations. Compared with the MDRD Study e...Continue Reading

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References

Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M J LandrayD C Wheeler
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Jun 29, 2002·Journal of the American Academy of Nurse Practitioners·Mary Jo Goolsby
Oct 3, 2002·Circulation·Hans L HillegeUNKNOWN Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group
Nov 21, 2002·JAMA : the Journal of the American Medical Association·Jackson T WrightUNKNOWN African American Study of Kidney Disease and Hypertension Study Group
Mar 13, 2003·Kidney International·Kunitoshi IsekiShuichi Takishita
Jul 2, 2005·Neuroepidemiology·Virginia J HowardGeorge Howard
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Michael G ShlipakMark J Sarnak
May 23, 2006·BMJ : British Medical Journal·Marcello TonelliUNKNOWN Cholesterol and Recurrent Events (CARE) Trial Investigators
Jun 16, 2006·American Journal of Epidemiology·Anoop ShankarBarbara E K Klein
Jun 23, 2006·Journal of the American Society of Nephrology : JASN·Stein I HallanJostein Holmen
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Jan 11, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·LuXia ZhangHaiYan Wang
Mar 3, 2007·Clinical Chemistry·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Mar 31, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Masaaki NakayamaYutaka Imai
Apr 11, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Claudine T JurkovitzWendy Weinstock Brown
Apr 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Meda E PavkovRobert G Nelson
Jun 24, 2008·The American Journal of Cardiology·Nisha I ParikhCaroline S Fox
Sep 23, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Adeera LevinLee Er
Oct 1, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anh L BuiMichael G Shlipak
Oct 1, 2008·BMJ : British Medical Journal·Emily CroweUNKNOWN Guideline Development Group
Nov 14, 2008·Journal of the American Society of Nephrology : JASN·Olivier MoranneUNKNOWN NephroTest Study Group
Feb 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tazeen H JafarShiraz Hashmi
Apr 8, 2009·American Journal of Nephrology·Michael G ShlipakMark J Sarnak
Apr 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Paul J RoderickAstrid E Fletcher
Aug 4, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·H J G BiloN Kleefstra
Sep 5, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·W Greg Miller
Sep 19, 2009·Journal of the American Society of Nephrology : JASN·Brad C AstorJosef Coresh
Jan 12, 2010·American Journal of Epidemiology·Simerjot K JassalElizabeth Barrett-Connor
Feb 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aleksandra KuklaHassan N Ibrahim
Mar 2, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kunihiro MatsushitaJosef Coresh
Mar 20, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Wieneke Marleen MichelsRaymond Theodorus Krediet
Jul 10, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Hilde TentGerjan Navis

❮ Previous
Next ❯

Citations

Jan 24, 2014·Current Opinion in Urology·Brian R LaneSteven C Campbell
Nov 19, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jordan M CloydBrendan C Visser
Oct 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kyrill S RogacevGunnar H Heine
Nov 26, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christoph SinningUNKNOWN Gutenberg Health Study
Dec 18, 2012·International Journal of Epidemiology·Kunihiro MatsushitaUNKNOWN Chronic Kidney Disease Prognosis Consortium
Dec 25, 2013·American Journal of Epidemiology·Lisa PennellsUNKNOWN Emerging Risk Factors Collaboration
Jul 5, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Belén PonteMurielle Bochud
May 16, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael MartinUNKNOWN Bangkok Tenofovir Study Group
Nov 28, 2013·Clinical and Experimental Nephrology·Sungjin ChungSeok Joon Shin
Nov 18, 2014·The New England Journal of Medicine·Robert W SchrierUNKNOWN HALT-PKD Trial Investigators
Aug 30, 2012·Journal of Women's Health·Todd W Gehr
Nov 1, 2012·JAMA : the Journal of the American Medical Association·Stein I HallanUNKNOWN Chronic Kidney Disease Prognosis Consortium
Jan 29, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Henry E WangDavid G Warnock
Jan 31, 2013·BMJ : British Medical Journal·Dorothea NitschUNKNOWN Chronic Kidney Disease Prognosis Consortium
Jan 1, 2012·Scientifica·Paul A F Jansen, Jacobus R B J Brouwers
Jan 19, 2013·Japanese Journal of Clinical Oncology·Yohei FunakoshiHironobu Minami
Mar 7, 2013·International Urology and Nephrology·Glen M BlakeDavid Goldsmith
Jun 20, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stein I Hallan, Ron T Gansevoort
Jun 20, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lesley A Inker, Andrew S Levey
Jun 20, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre DelanayeAndrew S Levey
Jan 17, 2016·The American Journal of Cardiology·Ayako KunimuraToyoaki Murohara
Nov 26, 2015·Néphrologie & thérapeutique·Pierre DelanayeChristophe Mariat
Sep 30, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Catharina M KorseRafael Molina
Mar 26, 2015·The American Journal of the Medical Sciences·Wei WangMichael E Griswold
Dec 3, 2014·International Journal of Cardiology·Yolande EsquirolUNKNOWN Prime study
Sep 5, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cristina M ArceUNKNOWN Women’s Health Initiative Investigators
Feb 4, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S LeveyJosef Coresh
Nov 13, 2013·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Aaltje Y AdemaUNKNOWN NIGRAM Consortium
Oct 1, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Saleem JessaniTazeen H Jafar
Oct 9, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xianwei WangUNKNOWN China National Stroke Registry Investigators
Oct 9, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·LaTonya J HicksonEric L Matteson
Jun 11, 2015·Nephrology·Giorgina Barbara PiccoliAndrea Veltri
Sep 28, 2013·Canadian Journal of Diabetes·Melissa SchorrUNKNOWN Alberta Kidney Disease Network
Jul 16, 2013·Clinics in Geriatric Medicine·Mitchell H Rosner
Nov 13, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Łukasz ZdrojewskiBolesław Rutkowski

❮ Previous
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