Comparison of risk profiles between survivors and victims of sudden cardiac death from an acute coronary event

Annals of Medicine
Kari S KaikkonenH V Huikuri

Abstract

This study was designed to compare the risk profiles of sudden cardiac death (SCD) victims and survivors of an acute coronary event. A case-control study included consecutive victims of SCD (n=425) verified to be due to an acute coronary event at medicolegal autopsy and consecutive patients surviving an acute myocardial infarction (AMI) (n=644). Family history of SCD (odds ratio (OR) 1.5, 95% confidence interval (CI) 1.0-2.2, P=0.03), male gender (OR 1.8, 95% CI 1.3-2.4, P<0.001), current smoking (OR 2.0, 95% CI 1.5-2.6, P<0.001), cardiac hypertrophy (OR 3.0, 95% CI 2.3-3.9, P<0.001) and three-vessel coronary artery disease (CAD) (OR 5.4, 95% CI 3.6-8.2, P<0.001) were more common among the victims of SCD as compared to survivors of AMI. There was a cumulative increase of risk of being a SCD victim versus AMI survivor when more than one risk factor was present, with the OR rising to 44.3 (95% CI 8.0-246.7) in a current male smoker with a family history of SCD and cardiac hypertrophy. There are specific features that differentiate the victims of SCD from survivors of an acute coronary event. Clustering of several variables, such as family history of SCD, smoking, cardiac hypertrophy and three-vessel CAD are alarm signals of a ver...Continue Reading

References

May 1, 1991·Journal of the American College of Cardiology·J K GhaliY L Liao
Dec 1, 1991·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·W B Kannel
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P CosteH Bricaud
Dec 3, 1988·BMJ : British Medical Journal·A C ThomasM J Davies
Jan 30, 1986·The New England Journal of Medicine·A P HallstromR Ray
Dec 1, 1984·Journal of the American College of Cardiology·R B DevereuxJ H Laragh
Mar 15, 1995·Circulation·G WannametheeM Walker
Jun 1, 1996·Circulation·L G Escobedo, M M Zack
May 1, 1997·The New England Journal of Medicine·A P BurkeR Virmani
Aug 15, 1998·American Heart Journal·W B KannelJ Cobb
Aug 26, 1998·European Heart Journal·H KaumaY A Kesäniemi
Nov 11, 1998·Journal of the American College of Cardiology·A W HaiderD Levy
Nov 24, 1998·Circulation·D P Zipes, H J Wellens
Apr 20, 1999·Circulation·X JouvenP Ducimetière
Jan 17, 2002·The New England Journal of Medicine·H V HuikuriR J Myerburg
Apr 16, 2003·Circulation·Christine M AlbertJoAnn E Manson
Jul 5, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Marcelo O Biagetti, Ricardo A Quinteiro
Sep 21, 2006·European Heart Journal·Da-Yi HuUNKNOWN China Heart Survey Group

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Citations

Sep 17, 2011·European Heart Journal·Jussi HonkolaHeikki V Huikuri
Nov 11, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Juha PerkiömäkiHeikki Huikuri
Jun 26, 2012·Circulation. Arrhythmia and Electrophysiology·Jani T TikkanenHeikki V Huikuri
Jul 17, 2019·Journal of Cardiovascular Electrophysiology·Santeri NortamoJuha S Perkiömäki
Jul 1, 2011·European Journal of Epidemiology·Hanna-Riikka LehtoVeikko Salomaa
Jul 11, 2019·JAMA Cardiology·Juha H VähätaloM Juhani Junttila
Feb 24, 2021·The American Journal of Cardiology·Juha VähätaloJuhani Junttila

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