Comparison of rocuronium and mivacurium to succinylcholine during outpatient laparoscopic surgery

Anesthesia and Analgesia
J TangP F White

Abstract

Tracheal intubating conditions and neuromuscular effects of succinylcholine, rocuronium, and mivacurium were studied in 100 healthy women undergoing outpatient laparoscopic surgery. After a standardized fentanyl-thiopental induction, tracheal intubation was facilitated with succinylcholine 1 mg/kg in Groups I (n = 23) and II (n = 25), rocuronium 0.6 mg/kg in Group III (n = 27), or mivacurium 0.2 mg/kg in Group IV (n = 25). If clinically indicated, bolus doses of rocuronium 5-10 mg (Groups I and III) or mivacurium 2-4 mg (Groups II and IV) were administered during the maintenance period. Anesthesia was maintained with desflurane and nitrous oxide 60% in oxygen. At the end of the surgery, residual neuromuscular block was reversed with edrophonium 0.5 mg/kg and atropine 10 micrograms/kg, if needed. The neuromuscular function was assessed using electromyography with a train-of-four mode of stimulation every 10 s at the wrist. Intubating conditions 90 s after succinylcholine and rocuronium were significantly better than after mivacurium. The onset time (from the end of injection until 95% suppression of the first twitch [T1]) for succinylcholine (63 +/- 21 s and 62 +/- 17 s in Groups I and II, respectively) were significantly shorte...Continue Reading

References

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Citations

Mar 24, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C Motamed, F Donati
Nov 7, 2000·Ambulatory Surgery·G P Joshi, R S Twersky
Jan 29, 2000·Anaesthesia·S F Wong, F Chung
Dec 23, 2014·Current Anesthesiology Reports·Hassan FarhanMatthias Eikermann
Dec 18, 2007·Journal of Clinical Anesthesia·Terrence K AllenTong J Gan
Jan 11, 2000·Emergency Medicine Clinics of North America·P S Wadbrook
Oct 30, 2015·The Cochrane Database of Systematic Reviews·Diem T T TranJeffrey J Perry
Oct 5, 2006·Current Opinion in Anaesthesiology·Thomas W Cutter

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