PMID: 8595540Feb 1, 1996Paper

Comparison of salmeterol with disodium cromoglycate in the treatment of adult asthma

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
J BousquetJ Bons

Abstract

Disodium cromoglycate and salmeterol, a long acting beta 2-agonist, achieve their therapeutic effects through different mechanisms but both are used as maintenance therapies in asthma. It was the purpose of this study to assess the comparative efficacy and safety of both drugs when used as prophylactic therapy for adults with symptomatic mild to moderate asthma. In this 8-week, double-blind, double-dummy, parallel group, multicenter study, 134 adult patients with a forced expiratory volume in one second (FEV1) ranging from 60% to 90% predicted, reversibility in FEV1 of greater than 15% and a total daily symptom score of at least 2 or a diurnal variation in peak expiratory flow (PEF) of greater than 15% on three of the seven days of the run-in period, were randomized to either salmeterol, 50 microgram twice daily (via metered-dose inhaler), or disodium cromoglycate, 20 mg four times daily (via Spinhaler), plus corresponding placebo. Approximately 50% of the total population were concurrently receiving inhaled corticosteroids. Salmeterol was significantly better than disodium cromoglycate in improving both morning (mean difference between treatments = 31 L/min; P = .007) and evening PEF (mean difference between treatments = 29 L/...Continue Reading

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Citations

Feb 7, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J WolfeE Stahl
Sep 26, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D W CockcroftM F Fitzpatrick
Mar 27, 2001·Family Practice·M EcclesUNKNOWN North of England Asthma Guideline Development Group
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Christopher J Cates, Matthew J Cates

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