Comparison of SD-Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration

Investigative Ophthalmology & Visual Science
Reinhard ToldUrsula Schmidt-Erfurth

Abstract

The purpose of this study is to compare the ability of spectral domain optical coherence tomography angiography (SD-OCTA) and indocyanine green angiography (ICGA) to detect and measure lesion area in patients with type 1 and 2 choroidal neovascularization (CNV). Types 1 and 2 neovascular AMD (nAMD) were included in this prospective and observational case series. ETDRS best-corrected visual acuity (BCVA), ophthalmic examination with funduscopy, OCTA (AngioVue), fluorescein angiography (FA), ICGA, and OCT (Spectralis) were performed. CNV measurements were done manually by two experienced graders using the systems' innate region selection tools. Forty eyes of 39 consecutive patients with nAMD were included. Mean age was 77 ± 6.4 years, ETDRS BCVA was 67 ± 13 letters, and 11 eyes were treatment naïve. Nineteen CNV lesions were classified as type 1 and 21 as type 2. ICGA was able to identify CNV in all eyes. By contrast, OCTA detected CNV in 95% of type 1 and 86% of type 2 nAMD eyes. Mean overall CNV area (CNV-A) was 2.8 ± 2.7 mm2 in ICGA and 2.1 ± 2.7 mm2 in OCTA. Both lesion types CNV-A appeared significantly smaller in OCTA compared with ICGA (P < 0.01). Bland-Altman plot revealed a mean difference (bias) between OCTA and ICGA CN...Continue Reading

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Citations

Sep 14, 2018·Journal of Ophthalmic Inflammation and Infection·Aniruddha AgarwalVishali Gupta
Oct 20, 2018·Current Neurology and Neuroscience Reports·Adam Wylęgała
Aug 22, 2020·Translational Vision Science & Technology·Giacomo CalzettiLeopold Schmetterer
Aug 23, 2020·The British Journal of Ophthalmology·Melina CavichiniWilliam R Freeman
Oct 6, 2020·Biomedical Optics Express·Acner CaminoYifan Jian
Oct 27, 2020·Translational Vision Science & Technology·Rodolfo MastropasquaLisa Toto

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