Comparison of sentinel lymph node biopsy guided by the multimodal method of indocyanine green fluorescence, radioisotope, and blue dye versus the radioisotope method in breast cancer: a randomized controlled trial

Annals of Surgical Oncology
So-Youn JungSeeyoun Lee

Abstract

This study aimed to evaluate the identification rate and surgery time of sentinel lymph node biopsy (SLNB) by a multimodal method (MMM) using a mixture of indocyanine green (ICG), radioisotope (RI), and blue dye (BD) compared with the RI alone. In this phase II randomized study, 86 patients with clinically node-negative breast cancer were enrolled and received SLNB with either MMM or RI. We compared the identification rate, number of sentinel lymph nodes (SLNs), and detection time of SLNB and evaluated the safety. The mean age of the MMM group and RI group was 48.2 and 51.0 years (p = 0.12), respectively. There were no differences in histopathologic factors, including tumor size, node positivity, and hormone receptor positivity between groups. SLNs were identified in all patients of both groups (100 % in the MMM group and 100 % in the RI group). The average number of SLNs in the MMM group was more than that in the RI group (3.4 ± 1.37 vs. 2.3 ± 1.04, respectively; p < 0.001). The time to detect the first sentinel lymph node was similar in each group (6.5 ± 5.16 vs. 8.0 ± 4.35 min; p = 0.13). In the MMM group, percutaneous lymphatic drainage was visualized by fluorescent imaging in 90.7 % (39 of 43 patients). During and after th...Continue Reading

References

Jul 1, 1986·The British Journal of Surgery·M W KissinG Westbury
Mar 12, 1997·JAMA : the Journal of the American Medical Association·A E Giuliano
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A E GiulianoR Statman
Oct 1, 1998·The New England Journal of Medicine·D KragP Beitsch
Mar 2, 1999·Journal of the National Cancer Institute·D Krag
Mar 18, 2000·Japanese Journal of Clinical Oncology·K MotomuraH Koyama
May 29, 2001·World Journal of Surgery·D ClarkeR E Mansel
Feb 20, 2002·The British Journal of Surgery·M Noguchi
Aug 9, 2003·The New England Journal of Medicine·Umberto VeronesiRoberto Gennari
Aug 20, 2005·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Toshiyuki KitaiTakahiro Shikayama
Oct 23, 2009·The British Journal of Surgery·D MurawaM Hünerbein
Feb 9, 2010·Breast Cancer Research and Treatment·Christoph HircheMichael Hünerbein
Feb 16, 2010·The Breast : Official Journal of the European Society of Mastology·Takashi HojoTakayuki Kinoshita
Jun 19, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G C WishartJ R Benson

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Citations

Dec 25, 2015·Gynécologie, obstétrique & fertilité·E CohenE Barranger
Mar 17, 2015·Journal of Dermatological Science·Kenji YokotaMasashi Akiyama
Jun 24, 2015·Radiology·Fijs W B van LeeuwenArian R van Erkel
Nov 21, 2014·The British Journal of Radiology·B Zhu, E M Sevick-Muraca
Jun 2, 2016·Medical Engineering & Physics·R J GrayD L Bader
Nov 21, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Tanner K Hill, Aaron M Mohs
Jun 21, 2016·Annales de chirurgie plastique et esthétique·Y GuenaneS Mazouz-Dorval
Aug 29, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Takafumi IkedaMasakazu Toi
Jan 20, 2015·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Eun Seong LeeSeok-Ki Kim
Nov 20, 2016·International Journal of Clinical Oncology·Tomoharu SugieMasakazu Toi
Jan 18, 2017·Nature Reviews. Clinical Oncology·Ray R ZhangJamey P Weichert
May 3, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sherko KuemmelThorsten Kuehn
Jan 5, 2019·Journal of breast cancer·Hee Jun ChoiSeok Won Kim
Apr 21, 2021·International Journal of Clinical Oncology·Sota AsagaHiroshi Kamma
Jul 9, 2021·American Journal of Otolaryngology·Nisha PatelRichard Keidan

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