Comparison of serologic responses between Kaposi's sarcoma-positive and -negative men who were seropositive for both human herpesvirus 8 and human immunodeficiency virus

Journal of Medical Virology
Naoki InoueWei Luo

Abstract

Although the introduction of HAART decreased substantially the incidence of Kaposi's sarcoma (KS), KS remains the most common cancer among individuals infected with human immunodeficiency virus (HIV). To define markers for progression to KS from the asymptomatic infection of human herpesvirus 8 (HHV-8), serologic responses against HHV-8 were compared between KS-negative and -positive men who were seropositive for both HIV and HHV-8. There was no difference in prevalence of detectable neutralizing antibodies between the two groups. The prevalence of anti-ORF73 antibodies among the dual seropositive patients increased in proportion to their risk of KS. In specimens obtained from 11 HIV+ patients at different intervals over a period of 4-12 years, increase of anti-ORF73 antibody titers was observed in the patients who developed KS but not in the patients who did not develop KS. These results suggest that there is a difference in serologic response against ORF73 between the HIV patients with and without KS.

References

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Citations

Jun 4, 2008·AIDS·Emmanuelle Boffi El AmariUNKNOWN Swiss HIV Cohort Study
Oct 6, 2006·Journal of Clinical Microbiology·A Scott LaneyPatrick S Moore
Sep 6, 2005·Virology Journal·Daniel C Edelman
Nov 7, 2014·Viruses·Veenu Minhas, Charles Wood
Jun 25, 2009·Journal of Medical Virology·Bishi FuLinding Wang
Jul 22, 2008·Journal of the American Academy of Dermatology·Robert A SchwartzLaura Scuderi

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