Comparison of Serum Human Epididymis Protein 4 and Carbohydrate Antigen 125 as Markers in Endometrial Cancer: A Meta-Analysis

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Lingli HuYing Li

Abstract

For patients with endometrial cancer (EC), the screening value of serum human epididymis protein 4 (HE4) remains controversial. We performed meta-analyses to compare the screening accuracy of serum HE4 and carbohydrate antigen 125 (CA125) for EC. A search of diagnostic test studies was performed in 5 English databases: Pubmed, Cochrane Library, Web of Science, Science Direct, and Elton Bryan Stephens Co or EBSCO; and 2 Chinese databases including China National Knowledge Infrastructure or CNKI and VIP (Weipu Database), from their inception dates to early July 2015. Two reviewers independently selected trials, conducted critical appraisal, and extracted data. Meta-analyses were performed to compare the screening accuracy between HE4 and CA125. Summary receiver operating characteristic curve and the area under the summary receiver operating characteristic curve were performed. Subgroup analysis, meta-regression, sensitivity analysis, and Egger plot and the Egger test were also conducted. Twenty-one studies were identified, and the methodological quality was generally fair. Meta-analyses revealed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratios for HE4 in sc...Continue Reading

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Citations

Oct 28, 2016·Expert Review of Molecular Diagnostics·Wanglei QuShi-Wen Jiang
Nov 29, 2016·Expert Review of Anticancer Therapy·Stella CapriglioneRoberto Angioli
Jan 25, 2017·Expert Review of Molecular Diagnostics·Wanglei QuShi-Wen Jiang
Jun 19, 2017·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Beata KotowiczMaria Kowalska
Apr 5, 2017·Journal of Clinical Laboratory Analysis·Marco BenatiGiuseppe Lippi
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Annalisa Di CelloFrancesco Costanzo
Feb 22, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Karin AbbinkLeon Fag Massuger
May 1, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Mar 5, 2019·Cancer Biomarkers : Section a of Disease Markers·Aneta Cymbaluk-PłoskaJanusz Menkiszak

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