PMID: 15335178Sep 1, 2004Paper

Comparison of serum IgA and IgG antibodies for detecting Helicobacter pylori infection

Internal Medicine
Yoshihisa UritaKazumasa Miki

Abstract

Although the diagnostic utility of serum IgG antibodies to Helicobacter pylori (H. pylori) is well established, the usefulness of IgA-based tests is less well documented. The aim of this study was to evaluate two commercially available ELISAs, both for IgG and IgA. Rapid urease test and histology analysis were performed in 183 patients. A patient was considered to be H. pylori-positive when either biopsy test was positive, and considered to be noninfected when both tests were negative. Intestinal metaplasia was determined by dye endoscopy with methylene blue. ELISA testing was performed using the EPI HM-CAP IgG and PP-CAP IgA assays and EIAgen IgG and IgA assays. Sensitivity was 94.7, 93.9, 94.8, and 97.0% for HM-CAP IgG, PP-CAP IgA, EIAgen IgG, and EIAgen IgA, respectively. Although sensitivity was excellent for both IgG and IgA antibodies, specificity of both IgA EIAs was low (PP-CAP 72.6%, EIAgen H. pylori IgA 59.2%). Three of 101 H. pylori-infected patients were PP-CAP positive and HM-CAP negative and four were EIAgen H. pylori IgA positive and EIAgen IgG negative. Of eight noninfected patients in whom intestinal metaplasia was found, PP-CAP IgA results were positive in three of five patients with a HM-CAP IgG negative resu...Continue Reading

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Citations

Nov 15, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Shailaja ShuklaAnurag Rohtagi
Jul 19, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Eva NártováJaromír Astl
Oct 10, 2013·International Journal of Medical Microbiology : IJMM·Mohammad Khalifeh GholiMarkus Gerhard
Dec 7, 2011·FEMS Immunology and Medical Microbiology·Marijke B M L ReyndersAnne Dediste
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Jun 12, 2009·Clinical and Vaccine Immunology : CVI·Rosemary C SheChristine M Litwin
Jun 17, 2020·Frontiers in Immunology·Adrien BosseboeufSylvie Hermouet

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