Abstract
To avoid the abuse and misuse of antibiotics, procalcitonin (PCT) and C-reactive protein (CRP) have been used as new approaches to identify different types of infection. Multiple databases were adopted to search relevant studies, and the articles that satisfied the inclusion criteria were included. Meta-analyses were conducted with Review Manager 5.0, and to estimate the quality of each article, risk of bias was assessed. Eight articles satisfied the inclusion criteria. The concentrations of both PCT and CRP in patients with bacterial infection were higher than those with non-bacterial infection. Both PCT and CRP levels in patients with G- bacterial infection were higher than in those with G+ bacterial infection and fungus infection. In the G+ bacterial infection group, a higher concentration of CRP was observed compared with fungus infection group, while the difference of PCT between G+ bacterial infection and fungus infection was not significant. Our study suggested that both PCT and CRP are helpful to a certain extent in detecting pneumonia caused by different types of infection.
References
Apr 1, 1996·QJM : Monthly Journal of the Association of Physicians·A D FergusonC R Swinburn
Mar 1, 1997·Chest·C M LunaE C Jolly
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·J RelloJ Valles
Aug 9, 1997·BMJ : British Medical Journal·P LittleA L Kinmonth
Aug 1, 1997·The Pediatric Infectious Disease Journal·D L Jaye, K B Waites
Jan 27, 1998·Archives of Family Medicine·A G Mainous, W J Hueston
Feb 23, 1999·Chest·M H KollefV J Fraser
Apr 13, 1999·Critical Care Medicine·H UgarteJ L Vincent
May 16, 2000·Critical Care Medicine·B MüllerR Ritz
Jun 14, 2000·Annals of Medicine·T W Du Clos
Aug 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R GonzalesM A Sande
Apr 2, 2002·BMJ : British Medical Journal·Ron Winkens, Geert-Jan Dinant
Feb 28, 2004·Lancet·Mirjam Christ-CrainBeat Müller
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Apr 26, 2006·European Journal of Pediatrics·Ryszard LauterbachKrzysztof Rytlewski
Jul 15, 2006·American Journal of Respiratory and Critical Care Medicine·Nick A MaskellRobert J O Davies
Jan 16, 2007·Chest·Daiana StolzMichael Tamm
Jun 23, 2009·The European Respiratory Journal·J M PorcelA Esquerda
Oct 25, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·H AltunhanI Mehmetoğlu
Dec 20, 2012·PloS One·Fiona J McCannY C Gary Lee
Apr 11, 2013·Clinical Biochemistry·Seung Hyeun LeeSang Yeub Lee
Oct 10, 2013·Respiratory Care·Ilias PorfyridisAndreas Georgiou
Citations
Mar 17, 2020·Analytical and Bioanalytical Chemistry·Rongbin NieLi Yang
Feb 23, 2020·Disease Markers·Liying LaiGuozhong Gong
Apr 4, 2020·Medicine·Haiying ChenYang Wang
Sep 11, 2020·Journal of Oncology·Shanshan DingLisheng Liu
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Yaling LiXiuhao Guan
Jan 16, 2021·Irish Journal of Medical Science·Walid A AliRaghda R S Hussein
Mar 7, 2021·Annals of Intensive Care·Cédric DaubinUNKNOWN from the PROCALCIVIR and BPCTrea study group
Mar 26, 2021·PeerJ·Rentian CaiZhen Tao
Apr 1, 2021·International Wound Journal·Xin XueLiqing Ren
Apr 4, 2021·Antibiotics·Raquel CarbonellAlejandro Rodríguez
Jun 3, 2021·Pharmaceutics·Khaled S AllemailemMasood A Khan
Nov 28, 2021·BMC Pulmonary Medicine·Yang LiXin Zhang