Comparison of serum PCT and CRP levels in patients infected by different pathogenic microorganisms: a systematic review and meta-analysis

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Jun-Hua TangPeng-Fei Zou

Abstract

To avoid the abuse and misuse of antibiotics, procalcitonin (PCT) and C-reactive protein (CRP) have been used as new approaches to identify different types of infection. Multiple databases were adopted to search relevant studies, and the articles that satisfied the inclusion criteria were included. Meta-analyses were conducted with Review Manager 5.0, and to estimate the quality of each article, risk of bias was assessed. Eight articles satisfied the inclusion criteria. The concentrations of both PCT and CRP in patients with bacterial infection were higher than those with non-bacterial infection. Both PCT and CRP levels in patients with G- bacterial infection were higher than in those with G+ bacterial infection and fungus infection. In the G+ bacterial infection group, a higher concentration of CRP was observed compared with fungus infection group, while the difference of PCT between G+ bacterial infection and fungus infection was not significant. Our study suggested that both PCT and CRP are helpful to a certain extent in detecting pneumonia caused by different types of infection.

References

Apr 1, 1996·QJM : Monthly Journal of the Association of Physicians·A D FergusonC R Swinburn
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·J RelloJ Valles
Aug 1, 1997·The Pediatric Infectious Disease Journal·D L Jaye, K B Waites
Jan 27, 1998·Archives of Family Medicine·A G Mainous, W J Hueston
Apr 13, 1999·Critical Care Medicine·H UgarteJ L Vincent
Jun 14, 2000·Annals of Medicine·T W Du Clos
Aug 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R GonzalesM A Sande
Apr 2, 2002·BMJ : British Medical Journal·Ron Winkens, Geert-Jan Dinant
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Apr 26, 2006·European Journal of Pediatrics·Ryszard LauterbachKrzysztof Rytlewski
Jul 15, 2006·American Journal of Respiratory and Critical Care Medicine·Nick A MaskellRobert J O Davies
Jun 23, 2009·The European Respiratory Journal·J M PorcelA Esquerda
Oct 25, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·H AltunhanI Mehmetoğlu

❮ Previous
Next ❯

Citations

Mar 17, 2020·Analytical and Bioanalytical Chemistry·Rongbin NieLi Yang
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Yaling LiXiuhao Guan

❮ Previous
Next ❯

Software Mentioned

Review Manager
STATA

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.