Comparison of serum tumor necrosis factor-α levels in rheumatoid arthritis individuals with and without chronic periodontitis: A biochemical study

Journal of Indian Society of Periodontology
Sivasankari ThilagarNizar Ahamed

Abstract

Tumor necrosis factor-alpha (TNF-α) is indicated to play a major function in chronic inflammatory disorders. To assess and compare the cytokine level (TNF-α) in the serum of chronic periodontitis (CP), rheumatoid arthritis (RA), RA with CP, and healthy volunteers. This original research was carried out on 80 participants, divided into Group-I 20 RA patients, Group-II 20 CP patients, Group III 20 RA with CP (RA + CP), and Group IV 20 healthy volunteers. Clinical periodontal and rheumatological parameters were assessed in all the four groups. Blood serum samples have been collected from all individuals and investigated for levels of TNF-α by mean of enzyme-linked immunosorbent assay. TNF-α level were remarkably elevated in the RA+CP group (30.5±2.2) followed by RA group (17.9 ± 3.6), and CP group (11.9 ± 0.96) when compared with the controls (5.5 ± 3.3). The results showed a statistical significance of P < 0.001. Correlation was not observed on comparision of clinical periodontal parameters and Rheumatological parameters with TNF-α levels. The outcome of this present research revealed the presence of higher levels of TNF-α in individuals with RA with CP in our samples.

Citations

Jul 13, 2019·International Journal of Molecular Sciences·Kübra Bunte, Thomas Beikler
Nov 5, 2020·Cytokine·Nidhi MedaraNeil M O'Brien-Simpson
Jan 22, 2020·Joint, Bone, Spine : Revue Du Rhumatisme·Codrina AncuțaOana Țănculescu

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.