Comparison of seven different anesthesia protocols for nicotine pharmacologic magnetic resonance imaging in rat

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Jaakko PaasonenOlli H Gröhn

Abstract

Pharmacologic MRI (phMRI) is a non-invasive in vivo imaging method, which can evaluate the drug effects on the brain and provide complementary information to ex vivo techniques. The preclinical phMRI studies usually require anesthesia to reduce the motion and stress of the animals. The anesthesia, however, is a crucial part of the experimental design, as it may modulate the neural drug-induced (de)activation and hemodynamic coupling. Therefore, the aim of the present study was to address this methodologic question by performing phMRI experiments with five anesthetics (α-chloralose, isoflurane, medetomidine, thiobutabarbital, and urethane) and seven anesthesia protocols. Nicotine, a widely studied psychostimulant, was administered to rats while measuring blood oxygenation level-dependent (BOLD) signals. Notably different responses were observed depending on the anesthetic used. The highest responses were measured in urethane-anesthetized rats whereas the responses were hardly noticeable in α-chloralose group. As urethane is not commonly used in phMRI, hemodynamic coupling under urethane anesthesia was investigated with functional cerebral blood flow (CBF) and volume-weighted (CBVw) imaging, and simultaneous electrophysiologic an...Continue Reading

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Citations

Oct 25, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jaakko PaasonenOlli Gröhn
Dec 3, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Junqiang MaIan R Winship
Apr 25, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Artem ShatilloOlli H Gröhn
Mar 10, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Haiyun QiChristoffer Laustsen
Jan 10, 2017·Journal of Neural Engineering·Lauri J LehtoShalom Michaeli
Apr 14, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lewis H MervinHamid R Noori
Sep 17, 2020·Translational Stroke Research·Michael S StringerJoanna M Wardlaw
Sep 15, 2020·The European Journal of Neuroscience·Cheng-Ting ShihShin-Lei Peng
May 27, 2021·Scientific Reports·Gergely SomogyiAndrás Czurkó

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