PMID: 8958890Nov 1, 1996Paper

Comparison of short courses of oral prednisolone and fluticasone propionate in the treatment of adults with acute exacerbations of asthma in primary care

Thorax
M L LevyT Maslen

Abstract

Oral corticosteroids used in short courses for acute asthma are regarded as safe, although the frequent use of these drugs may result in patients suffering from systemic side effects. It has become common practice for patients to increase their own inhaled corticosteroid intake when their asthma goes out of control, but it has never been established whether a high dose of inhaled corticosteroid can be as effective as a short course of oral corticosteroid in the treatment of acute exacerbations. A multicentre, randomised, double blind, double dummy, parallel group study was undertaken to determine whether the introduction of a high dose of inhaled fluticasone propionate (2 mg daily) is as effective as a short reducing course of oral prednisolone (starting at 40 mg/day and reducing by 5 mg every other day) in the treatment of acute exacerbations of asthma not considered severe enough for admission to hospital but requiring treatment with oral corticosteroid. Four hundred and thirteen adult asthmatic subjects who presented to their general practitioner with an acute exacerbation of asthma were recruited in 47 general practices in the United Kingdom. Treatment failures, defined as a reduction in peak expiratory flow (PEF) to below ...Continue Reading

References

Aug 1, 1990·Thorax·R Smith
Apr 22, 1989·BMJ : British Medical Journal·A J Nunn, I Gregg
Jan 1, 1989·Clinical Endocrinology·I R Reid
Mar 1, 1989·Thorax·R BeasleyS T Holgate
Nov 1, 1989·The American Review of Respiratory Disease·B G HigginsA E Tattersfield
Jun 11, 1988·British Medical Journal·C E BucknallR D Stevenson
Mar 1, 1987·New England and Regional Allergy Proceedings·J H Toogood
Jan 1, 1969·Dermatologia Internationalis·V C AndreevA J Rook
Nov 1, 1995·American Journal of Respiratory and Critical Care Medicine·M NoonanD Kellerman
Feb 6, 1993·Lancet·B R O'DriscollA A Woodcock
Mar 1, 1994·Archives of Disease in Childhood·G J ConnettW Lenney
Oct 1, 1993·Thorax·K P Jones
Feb 27, 1993·BMJ : British Medical Journal·R G NevilleB Smith

❮ Previous
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Citations

Jun 27, 2009·European Journal of Clinical Pharmacology·Kian Fan ChungIan M Adcock
Feb 11, 2004·Current Allergy and Asthma Reports·Matthew MasoliRichard Beasley
Feb 6, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Chitra Dinakar, Mamta Reddy
Jun 12, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kathleen Ververeli, Bradley Chipps
Aug 5, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S R NimmagaddaD Y Leung
Sep 7, 2000·The New England Journal of Medicine·S SchuhG Canny
Mar 27, 2001·Family Practice·M EcclesUNKNOWN North of England Asthma Guideline Development Group
Dec 12, 2002·Current Opinion in Pulmonary Medicine·Antonio Foresi, Pierluigi Paggiaro
May 17, 2007·Current Opinion in Pediatrics·Joseph D Spahn, Stanley J Szefler
Oct 15, 1998·Archives of Disease in Childhood·J GarrettD Holdaway
Oct 13, 2001·BMJ : British Medical Journal·M FitzGerald
Jun 30, 2004·Thorax·J M FitzGeraldUNKNOWN Canadian Asthma Exacerbation Study Group
Oct 31, 2006·Thorax·J M FitzGerald, P G Gibson
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·P G GibsonK Fakes
Oct 3, 2003·American Journal of Respiratory and Critical Care Medicine·E R McFadden
Mar 15, 2005·American Journal of Respiratory and Critical Care Medicine·Gustavo J Rodrigo
Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Feb 22, 2012·Asia Pacific Allergy·Pakit VichyanondSuruthai Kurasirikul
Mar 29, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Elif Yilmazel UcarMetin Akgun
Oct 3, 2014·Annals of Thoracic Medicine·Abdullah A Alangari
Oct 29, 1997·Lancet·B J Lipworth
Dec 22, 1998·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·A NanaE Ståhl
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A G Staresinic, C A Sorkness
Dec 14, 2002·Mayo Clinic Proceedings·Kaiser G Lim
Nov 8, 2008·Mayo Clinic Proceedings·Matthew A RankKaiser G Lim
Nov 30, 2005·Internal Medicine Journal·J A Douglass, H K Reddel
May 5, 2001·Clinical Pediatrics·B E Chipps, D R Chipps
Jun 9, 2016·The Cochrane Database of Systematic Reviews·Kayleigh M KewFrancine M Ducharme
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Marcia L EdmondsBrian H Rowe

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