Comparison of sib-pair and variance-components methods for genomic screening

Genetic Epidemiology
E W PughA F Wilson

Abstract

The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance-components method had better power for detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods.

References

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Citations

Dec 22, 1999·Genetic Epidemiology·D M MandalJ E Bailey-Wilson
Mar 27, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·U R RosyaraJ M Stein
May 6, 2003·Current Diabetes Reports·Robert L Hanson, William C Knowler
Jul 23, 2004·Nature·Michael MorleyVivian G Cheung
Mar 11, 2000·American Journal of Human Genetics·S C PrattL Kruglyak
Apr 14, 2000·American Journal of Human Genetics·W F Forrest, E Feingold
Dec 22, 1999·American Journal of Physical Anthropology·J RogersJ Blangero
Apr 9, 2002·European Journal of Human Genetics : EJHG·Yin Yao ShugartAlexander F Wilson
Jun 13, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K WalderE Ravussin
Jul 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Delphine FradinPierre Bougnères

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