Comparison of sirolimus-eluting stents with paclitaxel-eluting stents in saphenous vein graft intervention (from a multicenter Southern California Registry)

The American Journal of Cardiology
Michael S LeeWilliam French

Abstract

This study was designed to compare the safety and efficacy of sirolimus-eluting stents (SESs) to paclitaxel-eluting stents (PESs) in percutaneous intervention of saphenous vein graft (SVG) lesions. SVGs develop atherosclerosis at high rates and often require repeat revascularization. Percutaneous intervention with drug-eluting stents has become the preferred method of revascularization due to higher restenosis with bare metal stents and increased morbidity and mortality with repeat coronary artery bypass grafting. We sought to compare the rate of major adverse cardiac events and stent thrombosis between SESs and PESs in patients undergoing SVG intervention. A multicenter analysis of 172 patients with SVG lesions treated with SESs or PESs was performed. The 30-day and 1-year clinical outcomes of 102 patients receiving SESs were compared to those of 70 patients receiving PESs. There was no significant difference in baseline demographic, angiographic, and procedural characteristics between the SES and PES treatment groups. There was no statistical difference in major adverse cardiac events at 30 days and at 1 year (hazard ratio [HR] 1.58, 95% confidence interval [CI] 0.77 to 3.23, log-rank p = 0.21). There was also no difference i...Continue Reading

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Citations

Jul 11, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Kostantinos MarmagkiolisLuc Bilodeau
Oct 30, 2010·The American Journal of Cardiology·Emmanouil S Brilakis, Subhash Banerjee
Aug 20, 2011·JACC. Cardiovascular Interventions·Michael S LeeGregg W Stone
Apr 14, 2017·Circulation. Cardiovascular Interventions·Javaid IqbalUNKNOWN British Cardiovascular Intervention Society (BCIS) and National Institute of Cardiovascular Outcome Research (NICOR)
Jul 28, 2017·Cardiology and Therapy·Peter McKavanaghAsim Cheema
Mar 2, 2019·Current Treatment Options in Cardiovascular Medicine·Neda Dianati MalekiPuja B Parikh

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