Comparison of sirolimus versus paclitaxel eluting stents for treatment of coronary in-stent restenosis

The American Journal of Cardiology
Flavio AiroldiAntonio Colombo

Abstract

In patients with in-stent restenosis (ISR) inside bare metal stents, drug-eluting stents reduce the recurrence of restenosis compared with balloon angioplasty. However, few data are available about this therapeutic modality in the case of diffuse restenosis. The aim of this study was to evaluate the immediate and mid-term outcome of sirolimus- and paclitaxel-eluting stent implantation in diffuse ISR and determine the predictors of clinical and angiographic restenosis recurrence. A series of 161 consecutive patients with 194 diffuse ISR lesions (>10 mm) treated with drug-eluting stent implantation were evaluated. Major adverse cardiac events were defined as death, myocardial infarction, and the need for target lesion revascularization. During a mean follow-up of 8.2 +/- 3.4 months, the cumulative incidence of major adverse cardiac events was 19% in the SES group and 24% in the PES group (p = 0.56). Angiographic follow-up was performed in 80% of the lesions. The overall restenosis rate was 22% and was not significantly different between lesions treated with sirolimus-eluting (20%) or paclitaxel-eluting (25%, p = 0.55) stents. The incidence of restenosis was higher in diabetics (32%) than in nondiabetics (16%, odds ratio 2.5, 95% ...Continue Reading

References

Dec 1, 1992·Journal of the American College of Cardiology·B H StraussF T Bosman
Sep 15, 1996·The American Journal of Cardiology·R MehranM B Leon
Sep 19, 1998·Journal of the American College of Cardiology·A AbizaidM B Leon
Oct 12, 2000·JAMA : the Journal of the American Medical Association·J Al SuwaidiD R Holmes
Mar 27, 2001·Journal of the American College of Cardiology·S L GoldbergA Colombo
Jan 22, 2003·Journal of the American College of Cardiology·Muzaffer DegertekinPatrick W Serruys
Sep 16, 2003·The American Journal of Cardiology·Flavio AiroldiAntonio Colombo
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Jan 13, 2005·JAMA : the Journal of the American Medical Association·Adnan KastratiUNKNOWN ISAR-DESIRE Study Investigators
Feb 1, 2005·Journal of the American College of Cardiology·Carlo BriguoriAntonio Colombo
May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo

❮ Previous
Next ❯

Citations

Mar 5, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Helge MöllmannChristian W Hamm
May 9, 2008·Journal of Medical Systems·Richard P KonstanceDavid F Kong
Mar 24, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Amane IkeKeijiro Saku
Nov 16, 2006·International Heart Journal·Hiroshi SakamotoSeibu Mochizuki
Jan 6, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Clare E ApplebyFarzin Fath-Ordoubadi
Nov 2, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Rosli Mohd AliMartin Unverdorben
Sep 28, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Yvonne P CleverBruno Scheller
Aug 19, 2008·Journal of Interventional Cardiology·Konstantinos ToutouzasChristodoulos Stefanadis
Feb 8, 2014·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Hideaki AiharaUNKNOWN REAL-AI Registry Investigators
Oct 11, 2007·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Paolo CardaioliMassimo Giordan
Oct 25, 2006·Circulation·Young-Hak KimUNKNOWN Long-DES-II Study Investigators
May 16, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Probal RoyRon Waksman
Apr 4, 2017·Neurosurgical Focus·Nam K YoonMin S Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.