Comparison of slide coagglutination test and countercurrent immunoelectrophoresis for detection of group B streptococcal antigen in cerebrospinal fluid from infants with meningitis.

Journal of Clinical Microbiology
B J WebbC J Baker

Abstract

The usefulness of Phadebact streptococcus reagents for the detection of group B streptococcal antigen in cerebrospinal fluid was evaluated in 54 infants with meningitis and in 22 normal infants. Antigens was detected by slide coagglutination in 19 (82.6%) and by countercurrent immunoelectrophoresis in 20 (87.0%) of 23 cerebrospinal fluid specimens from infants with group B streptococcal meningitis at admission. After initiation of antimicrobial therapy, antigen could be detected in 11 of 19 (by slide coagglutination) and 7 of 18 (by countercurrent immunoelectrophoresis) cerebrospinal fluids. False-positive reactions were noted by slide coagglutination in one infant with S. bovis meningitis and one with group B streptococcal bacteremia without meningitis; none occurred with countercurrent immunoelectrophoresis. The commercial availiability, simplicity, sensitivity (82.6%), and specificity (96.4%) of the Phadebact slide coaggluatination test for detecting group B streptococcal antigen in cerebrospinal fluid suggest that it may be useful for the early and rapid diagnosis of group B streptococcal meningitis.

References

Sep 1, 1978·The Journal of Pediatrics·J D Siegel, G H McCracken
Jan 1, 1968·Acta Pathologica Et Microbiologica Scandinavica·I Lind, B Mansa
Mar 31, 1934·The Journal of Experimental Medicine·R C Lancefield

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Citations

Mar 1, 1988·Indian Journal of Pediatrics·A C Kuruvilla
Aug 1, 1981·Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology·B V PandyaT J Linna
Feb 1, 1992·Journal of Clinical Microbiology·L A TeixeiraL C Benchetrit
Nov 1, 1985·Diagnostic Microbiology and Infectious Disease·R C Tilton
Jul 1, 1982·Journal of Clinical Microbiology·M A WetkowskiL M de la Maza

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